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Substance Name: Propafenone [INN:BAN]
RN: 54063-53-5
UNII: 68IQX3T69U
InChIKey: JWHAUXFOSRPERK-UHFFFAOYSA-N

Note

  • An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.

Molecular Formula

  • C21-H27-N-O3

Molecular Weight

  • 341.448
 

Classification Codes

  • Anti-Arrhythmia Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Membrane Transport Modulators
  • Mutation Data
  • Sodium Channel Blockers
  • Voltage-Gated Sodium Channel Blockers

Names and Synonyms

Name of Substance

  • Propafenone
  • Propafenone [INN:BAN]

MeSH Heading

  • Propafenone

Synonyms

  • 1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone
  • EINECS 258-955-6
  • HSDB 7929
  • Propafenona
  • Propafenona [INN-Spanish]
  • Propafenone
  • Propafenonum
  • Propafenonum [INN-Latin]
  • UNII-68IQX3T69U

Systematic Names

  • 1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-
  • Propafenone

Registry Numbers

CAS Registry Number

  • 54063-53-5

FDA UNII

  • 68IQX3T69U

Related Registry Number

  • 34183-22-7 (hydrochloride)

System Generated Number

  • 0054063535

Structure Descriptors

InChI

1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3

InChIKey

JWHAUXFOSRPERK-UHFFFAOYSA-N

Smiles

c1(c(C(CCc2ccccc2)=O)cccc1)OC[C@@H](CNCCC)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man LDLo oral 4286ug/kg (4.286mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Postgraduate Medical Journal. Vol. 60, Pg. 155, 1984.
man TDLo oral 42858ug/kg/5D (42.858mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Therapie. Vol. 45, Pg. 161, 1990.
man TDLo oral 116mg/kg (116mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA
Annals of Emergency Medicine. Vol. 24, Pg. 98, 1994.
man TDLo unreported 251mg/kg/2Y-I (251mg/kg) LIVER: "JAUNDICE, CHOLESTATIC" Deutsche Medizinische Wochenschrift. Vol. 109, Pg. 1525, 1984.
mouse LD50 oral 440mg/kg (440mg/kg)   Japanese Journal of Toxicology. Vol. 4, Pg. 121, 1991.
women TDLo oral 36mg/kg/3D-I (36mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: TOXIC PSYCHOSIS

BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING
Journal of Clinical Psychiatry. Vol. 46, Pg. 104, 1985.
women TDLo oral 1404mg/kg/78D (1404mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" Annals of Internal Medicine. Vol. 104, Pg. 589, 1986.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.370 (none)   EST
Atmospheric OH Rate Constant 1.32E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.