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Substance Name: Propafenone [INN:BAN]
RN: 54063-53-5
UNII: 68IQX3T69U
InChIKey: JWHAUXFOSRPERK-UHFFFAOYSA-N
Note
- An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
Molecular Formula
- C21-H27-N-O3
Molecular Weight
- 341.448
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Arrhythmia Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Human Data
- Membrane Transport Modulators
- Mutation Data
- Sodium Channel Blockers
- Voltage-Gated Sodium Channel Blockers
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Links to Resources
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Names and Synonyms
Name of Substance
- Propafenone
- Propafenone [INN:BAN]
MeSH Heading
- Propafenone
Synonyms
- 1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone
- EINECS 258-955-6
- HSDB 7929
- Propafenona
- Propafenona [INN-Spanish]
- Propafenone
- Propafenonum
- Propafenonum [INN-Latin]
- UNII-68IQX3T69U
Systematic Names
- 1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-
- Propafenone
Registry Numbers
CAS Registry Number
- 54063-53-5
FDA UNII
- 68IQX3T69U
Related Registry Number
- 34183-22-7 (hydrochloride)
System Generated Number
- 0054063535
Structure Descriptors
InChI
1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3InChIKey
JWHAUXFOSRPERK-UHFFFAOYSA-NSmiles
c1(c(C(CCc2ccccc2)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | LDLo | oral | 4286ug/kg (4.286mg/kg) | CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Postgraduate Medical Journal. Vol. 60, Pg. 155, 1984. |
| man | TDLo | oral | 42858ug/kg/5D (42.858mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | Therapie. Vol. 45, Pg. 161, 1990. |
| man | TDLo | oral | 116mg/kg (116mg/kg) | CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA | Annals of Emergency Medicine. Vol. 24, Pg. 98, 1994. |
| man | TDLo | unreported | 251mg/kg/2Y-I (251mg/kg) | LIVER: "JAUNDICE, CHOLESTATIC" | Deutsche Medizinische Wochenschrift. Vol. 109, Pg. 1525, 1984. |
| mouse | LD50 | oral | 440mg/kg (440mg/kg) | Japanese Journal of Toxicology. Vol. 4, Pg. 121, 1991. | |
| women | TDLo | oral | 36mg/kg/3D-I (36mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: TOXIC PSYCHOSIS BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING | Journal of Clinical Psychiatry. Vol. 46, Pg. 104, 1985. |
| women | TDLo | oral | 1404mg/kg/78D (1404mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" | Annals of Internal Medicine. Vol. 104, Pg. 589, 1986. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 3.370 | (none) | EST | |
| Atmospheric OH Rate Constant | 1.32E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.