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Substance Name: Flecainide [INN:BAN]
RN: 54143-55-4
UNII: K94FTS1806
InChIKey: DJBNUMBKLMJRSA-UHFFFAOYSA-N

Note

  • A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.

Molecular Formula

  • C17-H20-F6-N2-O3

Molecular Weight

  • 414.344
 

Classification Codes

  • Anti-Arrhythmia Agents
  • Cardiovascular Agents
  • Membrane Transport Modulators
  • Sodium Channel Blockers
  • Voltage-Gated Sodium Channel Blockers

Names and Synonyms

Name of Substance

  • Flecainide
  • Flecainide [INN:BAN]

MeSH Heading

  • Flecainide

Synonyms

  • (+-)-Flecainide
  • CCRIS 313
  • Flecaine
  • Flecainida
  • Flecainida [INN-Spanish]
  • Flecainide
  • Flecainidum
  • Flecainidum [INN-Latin]
  • N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • UNII-K94FTS1806

Systematic Names

  • Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-
  • Flecainide

Registry Numbers

CAS Registry Number

  • 54143-55-4

FDA UNII

  • K94FTS1806

Other Registry Number

  • 99495-87-1

Related Registry Number

  • 54143-56-5 (monoacetate)

System Generated Number

  • 0054143554

Structure Descriptors

InChI

1S/C17H20F6N2O3/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26)

InChIKey

DJBNUMBKLMJRSA-UHFFFAOYSA-N

Smiles

c1cc(c(cc1OCC(F)(F)F)C(=O)NCC2CCCCN2)OCC(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women TDLo oral 40mg/kg (40mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
British Journal of Clinical Practice. Vol. 49, Pg. 218, 1995.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 145-147 deg C   EXP
log P (octanol-water) 3.78 (none)   EXP
Water Solubility 1.480 mg/L 25 EST
Vapor Pressure 7.29E-09 mm Hg 25 EST
Henry's Law Constant 5.75E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.47E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.