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Substance Name: Bis(chloromethyl) ether
RN: 542-88-1
UNII: 77382IHE37
InChIKey: HRQGCQVOJVTVLU-UHFFFAOYSA-N

Note

  • A substance that is an irritant to the eyes and respiratory tract and may be carcinogenic.

Molecular Formula

  • C2-H4-Cl2-O

Molecular Weight

  • 114.959
 

Classification Codes

Classification Codes

  • Human Data
  • Mutation Data
  • Tumor Data

Superlist Classification Codes

  • Known to be a Carcinogen
  • Overall Carcinogenic Evaluation: Group 1
  • Reportable Quantity (RQ) = 10 lb
  • Threshold Planning Quantity (TPQ) = 100 lb
  • TWA (0.001 ppm); Confirmed human carcinogen
  • TWA see 1910.1008

Names and Synonyms

Name of Substance

  • Bis(chloromethyl) ether
  • sym-Dichloromethyl ether

MeSH Heading

  • Bis(chloromethyl) ether

Synonyms

  • 1,1'-Dichlorodimethyl ether
  • 4-01-00-03051 (Beilstein Handbook Reference)
  • alpha,alpha'-Dichlorodimethyl ether
  • BCME
  • Bis(chloromethyl) ether
  • BRN 1679223
  • CCRIS 90
  • Chloro(chloromethoxy)methane
  • Chloromethyl ether
  • Dichlordimethylaether
  • Dichlordimethylaether [German]
  • Dichloromethyl ether, symmetrical
  • Dimethyl-1,1'-dichloroether
  • EINECS 208-832-8
  • Ether, bis(chloromethyl)
  • HSDB 501
  • Methane, oxybis(chloro-
  • Monochloromethyl ether
  • Oxybis(chloromethane)
  • RCRA waste number P016
  • sym-Dichloro-dimethyl ether
  • sym-Dichloromethyl ether
  • UNII-77382IHE37

Systematic Names

  • Bis(chloromethyl) ether
  • Ether, bis(chloromethyl)
  • Methane, 1,1'-oxybis(1-chloro-
  • Methane, oxybis(chloro-
  • Oxybis(chloromethane)

Superlist Names

  • Bis(chloromethyl) ether
  • Bis(chloromethyl)ether
  • Chloromethyl ether
  • Dichlorodimethyl ether, symmetrical
  • Dichlorodimethyl ether, symmetrical [UN2249] [Poison]
  • Dichloromethyl ether
  • Methane, oxybis(chloro-
  • RCRA waste no. P016
  • UN2249

Registry Numbers

CAS Registry Number

  • 542-88-1

FDA UNII

  • 77382IHE37

System Generated Number

  • 0000542881

Structure Descriptors

InChI

1S/C2H4Cl2O/c3-1-5-2-4/h1-2H2

InChIKey

HRQGCQVOJVTVLU-UHFFFAOYSA-N

Smiles

O(CCl)CCl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LC50 inhalation 7ppm/7H (7ppm) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BLOOD: HEMORRHAGE
Archives of Environmental Health. Vol. 30, Pg. 61, 1975.
man LCLo inhalation 100ppm/3M (100ppm) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Tijdschrift Voor Sociale Geneeskunde. Vol. 51, Pg. 596, 1973.
man TCLo inhalation 3ppm (3ppm) SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Tijdschrift Voor Sociale Geneeskunde. Vol. 51, Pg. 596, 1973.
mouse LC50 inhalation 25mg/m3/6H (25mg/m3)   Archives of Environmental Health. Vol. 22, Pg. 663, 1971.
rabbit LD50 skin 280uL/kg (0.28mL/kg)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat LC50 inhalation 7ppm/7H (7ppm) BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Archives of Environmental Health. Vol. 30, Pg. 61, 1975.
rat LD50 oral 210uL/kg (0.21mL/kg)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -4.15E+01 deg C   EXP
Boiling Point 106 deg C   EXP
log P (octanol-water) 0.570 (none)   EST
Water Solubility 2.20E+04 mg/L 25 EXP
Vapor Pressure 29.4 mm Hg 25 EXP
Henry's Law Constant 4.36E-03 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.10E-13 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.