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Substance Name: Clozapine hydrochloride
RN: 54241-01-9
UNII: 80862U56A3
InChIKey: ARWPDHKDEREYEE-UHFFFAOYSA-N

Note

  • A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

Molecular Formula

  • C18-H19-Cl-N4.Cl-H

Molecular Weight

  • 363.29
 

Names and Synonyms

Name of Substance

  • Clozapine hydrochloride

Synonyms

  • 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine monohydrochloride
  • UNII-80862U56A3

Systematic Name

  • 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 54241-01-9

FDA UNII

  • 80862U56A3

System Generated Number

  • 0054241019

Molecular Formulas

Molecular Formula

  • C18-H19-Cl-N4.Cl-H

Molecular Formula Fragments

  • C18-H19-Cl-N4
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H19ClN4.ClH/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18;/h2-7,12,20H,8-11H2,1H3;1H

InChIKey

ARWPDHKDEREYEE-UHFFFAOYSA-N

Smiles

Cl.CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24