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Substance Name: Heptaminol hydrochloride
RN: 543-15-7
UNII: XB3RM40HIR
InChIKey: JZNBMCOSOXIZJB-UHFFFAOYSA-N

Note

  • An amino alcohol that has been used as a myocardial stimulant and vasodilator and to relieve bronchospasm. Its most common therapeutic use is in orthostatic hypotension. The mechanism of heptaminol's therapeutic actions is not well understood although it has been suggested to affect catecholamine release or calcium metabolism.

Molecular Formula

  • C8-H19-N-O.Cl-H

Molecular Weight

  • 181.705
 

Classification Code

  • Human Data
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Names and Synonyms

Name of Substance

  • Heptaminol hydrochloride

Synonyms

  • 2-Heptylamine, 6-hydroxy-6-methyl-, hydrochloride
  • 2-Methyl-6-amino-2-heptanol hydrochloride
  • 6-Amino-2-methyl-2-heptanol hydrochloride
  • 6-Methyl-2-amino-6-heptanol hydrochloride
  • Arcor tropfen
  • Cardiosintol
  • Corasor
  • Coreptil
  • Cortensor
  • Delmiton
  • EA-85
  • EINECS 208-837-5
  • Eoden
  • Hept-a-myl tropfen
  • Heptaminol HCl
  • Heptaminol hydrochloride
  • Heptamyl hydrochloride
  • Heptamyl tropfen
  • Heptylon
  • Heptylon tropfen
  • Isoktamil
  • Izoktamil
  • R.P. 2831
  • Respirin
  • UNII-XB3RM40HIR

Systematic Names

  • 2-Heptanol, 6-amino-2-methyl-, hydrochloride
  • 6-Amino-2-methyl-2-heptanol hydrochloride
  • Heptaminol hydrochloride

Registry Numbers

CAS Registry Number

  • 543-15-7

FDA UNII

  • XB3RM40HIR

Other Registry Number

  • 53572-44-4

Related Registry Number

  • 372-66-7 (Parent)

System Generated Number

  • 0000543157

Molecular Formulas

Molecular Formula

  • C8-H19-N-O.Cl-H

Molecular Formula Fragments

  • C8-H19-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C8H19NO.ClH/c1-7(9)5-4-6-8(2,3)10;/h7,10H,4-6,9H2,1-3H3;1H

InChIKey

JZNBMCOSOXIZJB-UHFFFAOYSA-N

Smiles

Cl.CC(N)CCCC(C)(C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo unreported 670mg/kg (670mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 515, 1970.
human TDLo oral 28ug/kg (0.028mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER
Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 178, 1951.
mouse LD50 intraperitoneal 900mg/kg (900mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 178, 1951.