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Substance Name: Oxovinca
RN: 54341-01-4
UNII: EMQ36IS47K
InChIKey: ZZIDXUJHLCRNJB-YAFGAGFVSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H26-N2-O3.C5-H6-O5

Molecular Weight

  • 500.5448
 
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Names and Synonyms

Name of Substance

  • Oxovinca

Synonyms

  • EINECS 259-115-1
  • EL 485
  • Oxovinca
  • UNII-EMQ36IS47K
  • Vincamine 2-oxoglutarate
  • Vincamine alpha-ketoglutarate

Systematic Names

  • Eburnamenine-14-carboxylic acid, 14,15-dihydro-14-hydroxy-, methyl ester, (3-alpha,14-beta,16-alpha)-, 2-oxopentanedioate (1:1) (salt)
  • Methyl (3alpha,14beta,16alpha)-14,15-dihydro-14-hydroxyeburnamenine-14-carboxylate, 2-oxoglutarate (1:1)

Registry Numbers

CAS Registry Number

  • 54341-01-4

FDA UNII

  • EMQ36IS47K

System Generated Number

  • 0054341014

Molecular Formulas

Molecular Formula

  • C21-H26-N2-O3.C5-H6-O5

Molecular Formula Fragments

  • C21-H26-N2-O3
  • C5-H6-O5
  • COMPONENT

Structure Descriptors

InChI

1S/C21H26N2O3.C5H6O5/c1-3-20-10-6-11-22-12-9-15-14-7-4-5-8-16(14)23(17(15)18(20)22)21(25,13-20)19(24)26-2;6-3(5(9)10)1-2-4(7)8/h4-5,7-8,18,25H,3,6,9-13H2,1-2H3;1-2H2,(H,7,8)(H,9,10)/t18-,20+,21+;/m1./s1

InChIKey

ZZIDXUJHLCRNJB-YAFGAGFVSA-N

Smiles

CC[C@@]12CCCN3[C@@H]1c4c(c5ccccc5n4[C@](C2)(C(=O)OC)O)CC3.C(CC(=O)O)C(=O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 270mg/kg (270mg/kg)   United States Patent Document. Vol. #3982002,
mouse LD50 oral > 1gm/kg (1000mg/kg)   United States Patent Document. Vol. #3982002,
rat LD50 intraperitoneal 300mg/kg (300mg/kg)   United States Patent Document. Vol. #3982002,
rat LD50 oral > 1gm/kg (1000mg/kg)   United States Patent Document. Vol. #3982002,