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Substance Name: Doxercalciferol [USAN:INN]
RN: 54573-75-0
UNII: 3DIZ9LF5Y9
InChIKey: HKXBNHCUPKIYDM-CGMHZMFXSA-N

Note

  • Decreases number of osteoclast areas in normal rats.

Molecular Formula

  • C28-H44-O2

Molecular Weight

  • 412.6536
 

Classification Codes

  • Bone Density Conservation Agents
  • Growth Substances
  • Micronutrients
  • Treatment of Secondary Hyperparathroidism Associated with End-Stage Renal Disease (Calcium Regulator; Vitamin D Analog)
  • Vitamins

Names and Synonyms

Name of Substance

  • 1alpha-Hydroxyergocalciferol
  • Doxercalciferol [USAN:INN]

Synonyms

  • (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1alpha,3beta-diol
  • 1-alpha-Hydroxyvitamin D2
  • 1-Hydroxyergocalciferol
  • 1alpha-Hydroxyergocalciferol
  • BRN 4716774
  • Doxercalciferol
  • Hectorol
  • TSA 840
  • UNII-3DIZ9LF5Y9

Systematic Names

  • 9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol, (1-alpha,3-beta,5Z,7E,22E)-
  • 9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol, (1alpha,3beta,5Z,7E,22E)-

Registry Numbers

CAS Registry Number

  • 54573-75-0

FDA UNII

  • 3DIZ9LF5Y9

Other Registry Numbers

  • 125285-48-5
  • 87649-67-0

System Generated Number

  • 0054573750

Structure Descriptors

InChI

1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1

InChIKey

HKXBNHCUPKIYDM-CGMHZMFXSA-N

Smiles

C[C@H](/C=C/[C@H](C)C(C)C)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral 3500ug/kg (3.5mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 178, Pg. 432, 1985.