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Substance Name: Sulfadiazine sodium [USP:INN]
RN: 547-32-0
UNII: 84CS1P306F
InChIKey: JLDCNMJPBBKAHH-UHFFFAOYSA-N

Note

  • One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.

Molecular Formula

  • C10-H10-N4-O2-S.Na

Molecular Weight

  • 272.2631
 

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Sulfadiazine sodium [USP:INN]

Synonyms

  • 2-Sulfanilamidopyrimidine sodium salt
  • Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, monosodium salt
  • EINECS 208-919-0
  • Monosodium 2-sulfanilamidopyrimidine
  • N(sup 1)-2-Pyrimidinylsulfanilamide monosodium salt
  • N1-2-Pyrimidinylsulfanilamide monosodium salt
  • NSC 117870
  • NSC117870
  • Sodium sulfadiazine
  • Sodium sulfapyrimidine
  • Sodium, (N(sup 1)-2-pyrimidinylsulfanilamido)-
  • Solfadiazina sodica
  • Solfadiazina sodica [DCIT]
  • Soluble sulfadiazine
  • Soludiazine
  • Sulfadiazin-natrium
  • Sulfadiazina sodica
  • Sulfadiazina sodica [INN-Spanish]
  • Sulfadiazine sodique
  • Sulfadiazine sodique [INN-French]
  • Sulfadiazine sodium
  • Sulfadiazinum natricum
  • Sulfadiazinum natricum [INN-Latin]
  • Sulfanilamide, N(sup 1)-2-pyrimidinyl-, monosodium salt
  • Sulfanilamide, N(sup 1)-2-pyrimidinyl-, N(sup 1)-sodium deriv
  • Sulphadiazine
  • Suthogen
  • UNII-84CS1P306F

Systematic Names

  • Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, monosodium salt
  • Sulfadiazine sodium
  • Sulfanilamide, N(sup 1)-2-pyrimidinyl-, monosodium salt
  • Sulfanilamide, N1-2-pyrimidinyl-, monosodium salt (8CI)

Registry Numbers

CAS Registry Number

  • 547-32-0

FDA UNII

  • 84CS1P306F

System Generated Number

  • 0000547320

Molecular Formulas

Molecular Formula

  • C10-H10-N4-O2-S.Na

Molecular Formula Fragments

  • C10-H10-N4-O2-S
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C10H9N4O2S.Na/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1

InChIKey

JLDCNMJPBBKAHH-UHFFFAOYSA-N

Smiles

c1(S([N-]c2ncccn2)(=O)=O)ccc(N)cc1.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1747mg/kg (1747mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 17, 1944.
mouse LD50 intravenous 540mg/kg (540mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 94, Pg. 338, 1953.
mouse LD50 oral 1700mg/kg (1700mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 94, Pg. 338, 1953.
mouse LD50 subcutaneous 1408mg/kg (1408mg/kg)   Acta Medica Scandinavica, Supplement. Vol. 142, Pg. 64, 1943.