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Substance Name: Lucanthone hydrochloride [USAN:USP]
RN: 548-57-2
UNII: 918K9N56QZ
InChIKey: LAOOXBLMIJHMFO-UHFFFAOYSA-N

Note

  • One of the SCHISTOSOMICIDES, it has been replaced largely by HYCANTHONE and more recently PRAZIQUANTEL. (From Martindale The Extrapharmacopoeia, 30th ed., p46)

Molecular Formula

  • C20-H24-N2-O-S.Cl-H

Molecular Weight

  • 376.9495
 

Classification Codes

  • Antischistosomal
  • Drug / Therapeutic Agent
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Lucanthone hydrochloride
  • Lucanthone hydrochloride [USAN:USP]

Synonyms

  • 1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one monohydrochloride
  • 1-((2-Diethylaminoethyl)amino)-4-methylthioxanthen-9-one hydrochloride
  • 1-(2-Diethylaminoethylamino)-4-methylthiaxanthone hydrochloride
  • 1-(beta-Diethylaminoethylamino)-4-methylthiaxanthone hydrochloride
  • 1-Diaethylamino-aethylamino-4-methyl-thioxanthonhydrochlorid
  • 1-Diaethylamino-aethylamino-4-methyl-thioxanthonhydrochlorid [German]
  • 3735 R. P.
  • 3735 R.P.
  • 79 T61
  • 79T61
  • 9H-Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-methyl-, monohydrochloride
  • AI3-52847
  • B.W. 57-233
  • BW 57-233
  • BW 57223
  • CBC 900139
  • DR-15771
  • EINECS 208-951-5
  • HSDB 7095
  • Lucanthone HCl
  • Lucanthone hydrochloride
  • Lucanthone monohydrochloride
  • Miracil D
  • Miracol
  • Ms. 752
  • NIH 3127
  • Nilodin
  • NSC 14574
  • Scapuren
  • Schistosomicide
  • Tixantone
  • UNII-918K9N56QZ

Systematic Names

  • 9H-Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-methyl-, monohydrochloride
  • Lucanthone hydrochloride
  • Thioxanthen-9-one, 1-(2-(diethylaminoethyl)amino)-4-methyl-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 548-57-2

FDA UNII

  • 918K9N56QZ

System Generated Number

  • 0000548572

Molecular Formulas

Molecular Formula

  • C20-H24-N2-O-S.Cl-H

Molecular Formula Fragments

  • C20-H24-N2-O-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C20H24N2OS.ClH/c1-4-22(5-2)13-12-21-16-11-10-14(3)20-18(16)19(23)15-8-6-7-9-17(15)24-20;/h6-11,21H,4-5,12-13H2,1-3H3;1H

InChIKey

LAOOXBLMIJHMFO-UHFFFAOYSA-N

Smiles

CCN(CC)CCNc1ccc(c2c1c(=O)c3ccccc3s2)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 181mg/kg (181mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 intravenous 45mg/kg (45mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 20, Pg. 31, 1947.
mouse LDLo subcutaneous > 500mg/kg (500mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 20, Pg. 31, 1947.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 195.5 deg C   EXP
log P (octanol-water) 4.520 (none)   EST
Atmospheric OH Rate Constant 2.39E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.