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Substance Name: Fluoxetine [USAN:INN:BAN]
RN: 54910-89-3
UNII: 01K63SUP8D
InChIKey: RTHCYVBBDHJXIQ-UHFFFAOYSA-N
Note
- The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
Molecular Formula
- C17-H18-F3-N-O
Molecular Weight
- 309.329
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antidepressant
- Antidepressive Agents
- Antidepressive Agents, Second-Generation
- Antiviral (COVID-19)
- Central Nervous System Agents
- Cytochrome P-450 CYP2D6 Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Human Data
- Membrane Transport Modulators
- Metabolic Side Effects of Drugs and Substances
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Psychotropic Drugs
- Reproductive Effect
- Serotonin Agents
- Serotonin Uptake Inhibitors
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Links to Resources
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Names and Synonyms
Name of Substance
- Fluoxetine
- Fluoxetine [USAN:INN:BAN]
MeSH Heading
- Fluoxetine
Synonyms
- (+) or (-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine
- (+) or (-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
- (+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine
- (+-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
- Adofen
- Animex-On
- Benzenepropamine, N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+-)-
- Benzenepropanamine, N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+-)-
- dl-3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
- Eufor
- Fluctine
- Fludac
- Fluoxac
- Fluoxeren
- Fluoxetina
- Fluoxetina [INN-Spanish]
- Fluoxetina [Spanish]
- Fluoxetine
- Fluoxetinum
- Fluoxetinum [INN-Latin]
- Fluxil
- Fontex
- N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine
- Portal
- Prozac
- Pulvules
- Reconcile
- Selfemra
- UNII-01K63SUP8D
Systematic Name
- Benzenepropanamine, N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+-)-
Registry Numbers
CAS Registry Number
- 54910-89-3
FDA UNII
- 01K63SUP8D
Other Registry Numbers
- 52341-67-0
- 57226-07-0
Related Registry Number
- 59333-67-4 (hydrochloride)
System Generated Number
- 0054910893
Structure Descriptors
InChI
InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3InChIKey
RTHCYVBBDHJXIQ-UHFFFAOYSA-NSmiles
CNCCC(Oc1ccc(cc1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 17mg/kg (17mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | American Journal of Emergency Medicine. Vol. 16, Pg. 328, 1998. |
man | TDLo | oral | 17mg/kg (17mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | American Journal of Emergency Medicine. Vol. 16, Pg. 328, 1998. |
mouse | LD50 | intraperitoneal | 87500ug/kg (87.5mg/kg) | Drugs of the Future. Vol. 15, Pg. 1178, 1990. | |
mouse | LD50 | oral | 464mg/kg (464mg/kg) | Drugs of the Future. Vol. 15, Pg. 1178, 1990. | |
rat | LD50 | intraperitoneal | 121mg/kg (121mg/kg) | Drugs of the Future. Vol. 15, Pg. 1178, 1990. | |
rat | LD50 | oral | 825mg/kg (825mg/kg) | Drugs of the Future. Vol. 15, Pg. 1178, 1990. | |
women | TDLo | oral | 2mg/kg/5D-I (2mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Archives of Internal Medicine. Vol. 156, Pg. 681, 1996. |
women | TDLo | oral | 16800ug/kg/6W (16.8mg/kg) | BEHAVIORAL: ANTIPSYCHOTIC BEHAVIORAL: MUSCLE WEAKNESS | Archives of Internal Medicine. Vol. 156, Pg. 681, 1996. |
women | TDLo | oral | 60mg/kg/21W-I (60mg/kg) | American Journal of Psychiatry. Vol. 153, Pg. 134, 1996. | |
women | TDLo | oral | 72mg/kg/26W-I (72mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of Clinical Pyschopharmacology. Vol. 10, Pg. 343, 1990. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 4.05 | (none) | EXP | |
Water Solubility | 60.3 | mg/L | 25 | EST |
Vapor Pressure | 2.52E-05 | mm Hg | 25 | EST |
Henry's Law Constant | 8.90E-08 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 3.69E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.