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Substance Name: Albendazole [USAN:USP:INN:BAN:JAN]
RN: 54965-21-8
UNII: F4216019LN
InChIKey: HXHWSAZORRCQMX-UHFFFAOYSA-N

Note

  • A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)

Molecular Formula

  • C12-H15-N3-O2-S

Molecular Weight

  • 265.3355
 

Classification Codes

  • Anthelmintic
  • Anthelmintics
  • Anti-Infective Agents
  • Anticestodal Agents
  • Antimitotic Agents
  • Antiparasitic Agents
  • Antiplatyhelmintic Agents
  • Antiprotozoal Agents
  • Drug / Therapeutic Agent
  • Mitosis Modulators
  • Mutation Data
  • Reproductive Effect
  • Tubulin Modulators

Names and Synonyms

Name of Substance

  • Albendazole
  • Albendazole [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Albendazole

Synonyms

  • ((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle
  • ((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle [French]
  • (5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester
  • 5-(Propylthio)-2-carbomethoxyaminobenzimidazole
  • Albendazol
  • Albendazol [INN-Spanish]
  • Albendazole
  • Albendazolum
  • Albendazolum [INN-Latin]
  • Albenza
  • Bilutac
  • Carbamic acid, (5-(propylthio)-1H-benzimidazol-2-yl)-, methyl ester
  • EINECS 259-414-7
  • Eskazole
  • HSDB 7444
  • Methyl 5-(propylthio)-2-benzimidazolecarbamate
  • NSC 220008
  • O-Methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate
  • Proftril
  • SK&F 62979
  • SKF 62979
  • UNII-F4216019LN
  • Valbazen
  • Zentel

Systematic Names

  • Albendazole
  • Carbamic acid, (5-(propylthio)-1H-benzimidazol-2-yl)-, methyl ester

Registry Numbers

CAS Registry Number

  • 54965-21-8

FDA UNII

  • F4216019LN

System Generated Number

  • 0054965218

Structure Descriptors

InChI

1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)

InChIKey

HXHWSAZORRCQMX-UHFFFAOYSA-N

Smiles

c12c(nc([nH]1)NC(=O)OC)cc(cc2)SCCC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. -, Pg. 99, 1995.
mouse LD50 oral 1500mg/kg (1500mg/kg)   Acta Leidensia. Vol. 57, Pg. 201, 1989.
rat LD50 intravenous 265mg/kg (265mg/kg)   Drugs in Japan Vol. -, Pg. 99, 1995.
rat LD50 oral 2400mg/kg (2400mg/kg)   Annales Pharmaceutiques Francaises. Vol. 40, Pg. 55, 1982.
women TDLo oral 256mg/kg/16D (256mg/kg) BLOOD: APLASTIC ANEMIA American Journal of Hematology. Vol. 53, Pg. 53, 1996.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 209 deg C   EXP
log P (octanol-water) 3.140 (none)   EST
Atmospheric OH Rate Constant 2.11E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.