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Substance Name: Levothyroxine Sodium [USAN:INN]
RN: 55-03-8
UNII: 054I36CPMN
InChIKey: YDTFRJLNMPSCFM-YDALLXLXSA-M

Note

  • Thyroid powder.

Molecular Formula

  • C15-H11-I4-N-O4.Na

Molecular Weight

  • 798.837
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
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Names and Synonyms

Results Name

  • Levothyroxine Sodium [USAN:INN]

Name of Substance

  • Levothyroxine Sodium [USAN:INN]
  • Thyradin

Synonyms

  • 3,3',5,5'-Tetraiodo-L-thyronine, sodium salt
  • Berlthyrox
  • Dathroid
  • Eferox
  • EINECS 200-221-4
  • Eltroxin
  • Euthyrox
  • L-Thyroxine monosodium salt
  • L-Thyroxine sodium
  • Laevoxin
  • Letter
  • Levaxin
  • Leventa
  • Levo-t
  • Levolet
  • Levoroxine
  • Levothroid
  • Levothyroxin-natrium
  • Levothyroxine sodique
  • Levothyroxine sodique [INN-French]
  • Levothyroxine sodium
  • Levothyroxine sodium tablets
  • Levothyroxinum natricum
  • Levothyroxinum natricum [INN-Latin]
  • Levotiroxina sodica
  • Levotiroxina sodica [INN-Spanish]
  • Levoxyl
  • Novothyrox
  • NSC 259940
  • Oroxine
  • Ro-thyroxine
  • Roxstan
  • Sodium l-thyroxin
  • Sodium L-thyroxine
  • Sodium levothyroxine
  • Sodium thyroxin
  • Sodium thyroxinate
  • Sodium thyroxine
  • Sodium-L-thyroxine
  • Soloxine
  • Synthroid
  • Synthroid sodium
  • Tetroid
  • Thevier
  • Thyradin
  • Thyradin S
  • Thyro-Tabs
  • Thyronamin
  • Thyrosit
  • Thyroxevan
  • Thyroxin sodium
  • Thyroxine sodique
  • Thyroxine sodium
  • Thyroxinique
  • Thyroxinum natricum
  • Tiroidina
  • Tirosint
  • Tirosint-Sol
  • Tyrosint
  • UNII-054I36CPMN
  • Unithroid

Systematic Names

  • L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt
  • L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1)
  • Levothyroxine sodium
  • Thyroxine, monosodium salt, L-

Registry Numbers

CAS Registry Number

  • 55-03-8

FDA UNII

  • 054I36CPMN

Other Registry Numbers

  • 50809-32-0
  • 67809-22-7

System Generated Number

  • 0000055038

Molecular Formulas

Molecular Formula

  • C15-H11-I4-N-O4.Na

Molecular Formula Fragments

  • C15-H11-I4-N-O4
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C15H11I4NO4.Na/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;/h1-2,4-5,12,21H,3,20H2,(H,22,23);/q;+1/p-1/t12-;/m0./s1

InChIKey

YDTFRJLNMPSCFM-YDALLXLXSA-M

Smiles

c1c(cc(c(c1I)Oc2cc(c(c(c2)I)O)I)I)C[C@@H](C(=O)[O-])N.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 20ug/kg (0.02mg/kg)   American Journal of Diseases of Children. Vol. 141, Pg. 1025, 1987.
child TDLo oral 20ug/kg (0.02mg/kg) BEHAVIORAL: EXCITEMENT

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
American Journal of Diseases of Children. Vol. 141, Pg. 1025, 1987.
child TDLo oral 449ug/kg (0.449mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Annals of Emergency Medicine. Vol. 14, Pg. 1114, 1985.
child TDLo oral 660ug/kg (0.66mg/kg)   Pediatrics. Vol. 45, Pg. 298, 1970.
child TDLo oral 660ug/kg (0.66mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Pediatrics. Vol. 45, Pg. 298, 1970.
child TDLo oral 900ug/kg (0.9mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

ENDOCRINE: EVIDENCE OF THYROID HYPOFUNCTION
American Journal of Emergency Medicine. Vol. 3, Pg. 297, 1985.
child TDLo oral 291mg/kg (291mg/kg) BEHAVIORAL: IRRITABILITY

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
New England Journal of Medicine. Vol. 256, Pg. 459, 1957.
rat LD50 intraperitoneal 20mg/kg (20mg/kg)   Drugs in Japan Vol. 6, Pg. 905, 1982.
rat LD50 subcutaneous 50mg/kg (50mg/kg)   Drugs in Japan Vol. 6, Pg. 905, 1982.
women TDLo oral 117ug/kg/60D- (0.117mg/kg) BEHAVIORAL: HEADACHE American Journal of Diseases of Children. Vol. 138, Pg. 927, 1984.
women TDLo oral 14mg/kg/14D-I (14mg/kg) BEHAVIORAL: COMA

CARDIAC: CHANGE IN RATE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
American Journal of Emergency Medicine. Vol. 3, Pg. 297, 1985.
women TDLo oral 48gm/kg/26W-I (48000mg/kg) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER
Archives of Internal Medicine. Vol. 148, Pg. 1450, 1988.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.340 (none)   EST
Water Solubility 150 mg/L 25 EXP
Atmospheric OH Rate Constant 3.14E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.