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Substance Name: Atropine sulfate anhydrous
RN: 55-48-1
UNII: KAE4PSB0Z3
InChIKey: HOBWAPHTEJGALG-AADVZIIPSA-N

Note

  • An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE.

Molecular Formula

  • C17-H23-N-O3.1/2H2-O4-S

Molecular Weight

  • 676.8232
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Atropine sulfate anhydrous

Synonyms

  • 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester), sulfate (2:1) salt
  • AI3-14072
  • Atropen
  • Atropette
  • Atropin siran
  • Atropin siran [Czech]
  • Atropine sulfate
  • Atropine sulfate (VAN)
  • Atropine sulphate
  • Atropine sulphate (VAN)
  • Atropine, sulfate (2:1)
  • Atropinium sulfate
  • Atropinsulfat
  • Atropinsulfat [German]
  • Atropiny siarczan
  • Atropiny siarczan [Polish]
  • Atropisol
  • Corbella
  • Davurtrop
  • DL-Tropanyl 2-hydroxy-1-phenylpropionate sulfate
  • EINECS 200-235-0
  • Eyesule
  • Ichtho-bellol
  • Lio-atropin
  • MBK
  • NSC 26671
  • Ryuato
  • Sulfate d'atropine
  • Sulfate d'atropine [French]
  • Sulfatropinol
  • Tropintran
  • UNII-KAE4PSB0Z3

Systematic Names

  • 1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester), sulfate (2:1) (salt) (8CI)
  • Atropine sulphate
  • Atropine, sulfate (2:1)
  • Benzeneacetic acid, alpha-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, sulfate (2:1)
  • Benzeneacetic acid, alpha-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, sulfate (2:1) (salt)
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+-)-, sulfate (2:1) (salt)

Registry Numbers

CAS Registry Number

  • 55-48-1

FDA UNII

  • KAE4PSB0Z3

Other Registry Number

  • 17108-73-5

System Generated Number

  • 0000055481

Molecular Formulas

Molecular Formula

  • C17-H23-N-O3.1/2H2-O4-S

Molecular Formula Fragments

  • C17-H23-N-O3
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/2C17H23NO3.H2O4S/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4)/t2*13-,14+,15+,16?;

InChIKey

HOBWAPHTEJGALG-AADVZIIPSA-N

Smiles

CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@@H]5CC[C@H]4C[C@H](C5)OC(=O)C(CO)c6ccccc6.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LDLo oral 226mg/kg (226mg/kg)   Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
bird - wild LDLo subcutaneous 200mg/kg (200mg/kg)   Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
cat LD50 intravenous 36mg/kg (36mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 35, Pg. 316, 1936.
cat LDLo subcutaneous 30mg/kg (30mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
chicken LDLo subcutaneous 750mg/kg (750mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
child TDLo oral 20ug/kg (0.02mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

BEHAVIORAL: EXCITEMENT

CARDIAC: CHANGE IN RATE
Archives of Disease in Childhood. Vol. 54, Pg. 222, 1979.
dog LD50 intravenous 60mg/kg (60mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Toxicology and Applied Pharmacology. Vol. 10, Pg. 424, 1967.
dog LDLo intraperitoneal 175mg/kg (175mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
dog LDLo subcutaneous 200mg/kg (200mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
duck LDLo subcutaneous 250mg/kg (250mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
frog LDLo subcutaneous 1200mg/kg (1200mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
guinea pig LD50 subcutaneous 480mg/kg (480mg/kg) AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962.
guinea pig LDLo intraarterial 90mg/kg (90mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig LDLo intraperitoneal 400mg/kg (400mg/kg)   Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
guinea pig LDLo intravenous 70mg/kg (70mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
human TDLo intramuscular 28ug/kg (0.028mg/kg) BEHAVIORAL: ATAXIA

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Journal of Applied Physiology. Vol. 8, Pg. 635, 1956.
man LDLo oral 357mg/kg (357mg/kg) GASTROINTESTINAL: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Hochudoku. Vol. 10, Pg. 184, 1992.
man TDLo intravenous 28ug/kg/11H-I (0.028mg/kg)   American Journal of Diseases of Children. Vol. 137, Pg. 291, 1983.
man TDLo unreported 14285ng/kg (0.014285mg/kg) SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: HEADACHE
Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 273, 1991.
monkey LDLo subcutaneous 150mg/kg (150mg/kg) BEHAVIORAL: MUSCLE WEAKNESS Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
mouse LD50 intraperitoneal 150mg/kg (150mg/kg)   Journal of the American Chemical Society. Vol. 79, Pg. 4451, 1957.
mouse LD50 intravenous 31mg/kg (31mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 637, 1966.
mouse LD50 oral 468mg/kg (468mg/kg) AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC Archives Internationales de Pharmacodynamie et de Therapie. Vol. 156, Pg. 467, 1965.
mouse LD50 subcutaneous 400mg/kg (400mg/kg)   Therapie. Vol. 12, Pg. 412, 1957.
pigeon LDLo subcutaneous 210mg/kg (210mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

GASTROINTESTINAL: NAUSEA OR VOMITING
Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
rabbit LD50 intramuscular 414mg/kg (414mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Canadian Medical Association Journal. Vol. 85, Pg. 1241, 1961.
rabbit LD50 intraperitoneal 200mg/kg (200mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Toxicology and Applied Pharmacology. Vol. 10, Pg. 424, 1967.
rabbit LD50 intravenous 70mg/kg (70mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Toxicology and Applied Pharmacology. Vol. 10, Pg. 424, 1967.
rabbit LDLo intracrebral 1mg/kg (1mg/kg)   Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 81, Pg. 193, 1917.
rabbit LDLo subcutaneous 100mg/kg (100mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 132, Pg. 63, 1928.
rat LD50 intraperitoneal 215mg/kg (215mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Toxicology and Applied Pharmacology. Vol. 11, Pg. 511, 1967.
rat LD50 intravenous 37mg/kg (37mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Toxicology and Applied Pharmacology. Vol. 11, Pg. 511, 1967.
rat LD50 oral 600mg/kg (600mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 393, 1965.
rat LD50 subcutaneous 540mg/kg (540mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 393, 1965.
women TDLo multiple routes 44ug/kg/1D-I (0.044mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Archives of Internal Medicine. Vol. 146, Pg. 45, 1986.
women TDLo ocular 20ug/kg/4H-I (0.02mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Archives of Internal Medicine. Vol. 146, Pg. 45, 1986.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 50.5 deg C   EXP
log P (octanol-water) 1.910 (none)   EST
Water Solubility 3940 mg/L 25 EST
Vapor Pressure 1.95E-08 mm Hg 25 EST
Henry's Law Constant 2.73E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.11E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.