Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Nitroglycerin [USP:JAN]
RN: 55-63-0
UNII: G59M7S0WS3
InChIKey: SNIOPGDIGTZGOP-UHFFFAOYSA-N

Note

  • A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.

Molecular Formula

  • C3-H5-N3-O9

Molecular Weight

  • 227.085
 

Classification Codes

Classification Codes

  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Explosive Agents
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data
  • Vasodilator (Coronary)
  • Vasodilator Agents

Superlist Classification Codes

  • Ceiling 0.2 ppm (2 mg/m3); skin
  • Reportable Quantity (RQ) = 10 lb
  • TWA (0.05 ppm); skin

Names and Synonyms

Name of Substance

  • Nitroglycerin
  • Nitroglycerin [USP:JAN]

MeSH Heading

  • Nitroglycerin

Synonyms

  • 1,2,3-Propanetriol, trinitrate
  • 1,2,3-Propanetriyl nitrate
  • 4-01-00-02762 (Beilstein Handbook Reference)
  • Adesitrin
  • Aldonitrin
  • Angibid
  • Anginine
  • Angiolingual
  • Angiplex
  • Anglix
  • Angonist
  • Angorin
  • Aquo-Trimitrosan
  • Blasting gelatin
  • Blasting oil
  • BRN 1802063
  • Buccard
  • Cardabid
  • Cardamist
  • Cardinit
  • Cardiodisco
  • CCRIS 4089
  • Chitamite
  • Colenitral
  • Corangin Nitrokapseln
  • Cordipatch
  • Corditrine
  • Coro-Nitro
  • Dauxona
  • Deponit
  • Deponit 5
  • Deponit TTS 10
  • Deponit TTS 5
  • Deponit-5
  • Diafusor
  • Discotrine
  • EC 200-240-8
  • EINECS 200-240-8
  • Epinitril
  • Gepan Nitroglicerin
  • Gilucor nitro
  • Gilustenon
  • Glonoin
  • Glonoinum
  • Glycerine trinitrate
  • Glycerintrinitrate
  • Glycerintrinitrate [Czech]
  • Glycerol (trinitrate de)
  • Glycerol (trinitrate de) [French]
  • Glycerol trinitrate
  • Glycerol(trinitrate de)
  • Glycerol(trinitrate de) [French]
  • Glycerol, nitric acid triester
  • Glyceroltrinitraat
  • Glyceroltrinitraat [Dutch]
  • Glyceryl
  • Glyceryl nitrate
  • Glyceryl trinitrate
  • Glycerylnitrat
  • Glytrin
  • Gonitro
  • GTN
  • GTN-Pohl
  • Herwicard
  • Herzer
  • HSDB 30
  • Klavikordal
  • Lenitral
  • Lentonitrina
  • Mi-Trates
  • Millisrol
  • Minitram
  • Minitran
  • Mionitrat
  • Myocon
  • Myoglycerin
  • Myovin
  • Natispray
  • Neos nitro OPT
  • NG
  • Niglin
  • Niglycon
  • Niong
  • Niong Retard
  • Nirmin
  • Nit-Ret
  • Nitora
  • Nitradisc
  • Nitradisc Pad
  • Nitradisc TTS
  • Nitrek
  • Nitric acid triester of gylcerol
  • Nitriderm TTS
  • Nitrin
  • Nitrine
  • Nitrine-TDC
  • Nitro Dur TTS
  • Nitro IV
  • Nitro Mack Retard
  • Nitro Retard
  • Nitro Rorer
  • Nitro-Bid
  • Nitro-Dur
  • Nitro-Dur 10
  • Nitro-Dur 5
  • Nitro-Gesanit Retard
  • Nitro-lent
  • Nitro-M-Bid
  • Nitro-Mack Retard
  • Nitro-Par
  • Nitro-Pflaster
  • Nitro-Span
  • Nitro-Time
  • Nitroard
  • Nitrobaat
  • NitroBid
  • Nitrobid Oint
  • Nitrobukal
  • NitrocapT.D.
  • Nitrocerin
  • Nitrocine
  • Nitrocine 5
  • Nitroclyn
  • Nitrocontin
  • Nitrocontin Continus
  • Nitrocor
  • Nitrocot
  • Nitroderm
  • Nitroderm TTS
  • Nitroderm TTS Ext
  • Nitroderm TTS-5
  • Nitrodisc
  • Nitrodyl
  • Nitrodyl TTS
  • Nitrogard
  • Nitrogard-SR
  • Nitroglicerina
  • Nitroglicerina [Italian]
  • Nitroglicerina [Spanish]
  • Nitrogliceryna
  • Nitrogliceryna [Polish]
  • Nitroglin
  • Nitroglycerin
  • Nitroglycerin in dextrose 5%
  • Nitroglycerin, spirits of
  • Nitroglycerin-ACC
  • Nitroglycerine
  • Nitroglycerine [French]
  • Nitroglycerol
  • Nitroglyn
  • Nitrol
  • Nitrol (pharmaceutical)
  • Nitrol Ointment
  • Nitrolan
  • Nitroletten
  • Nitrolin
  • Nitrolingual
  • Nitrolingual pumpspray
  • Nitrolingual Spray
  • Nitrolowe
  • Nitromack Retard
  • Nitromel
  • Nitromex
  • Nitromint
  • Nitromint Aerosol
  • Nitromint Retard
  • Nitromist
  • Nitronal
  • Nitronal Aqueous
  • Nitronet
  • Nitrong
  • Nitrong Retard
  • Nitrong-SR
  • Nitropatch
  • Nitropen
  • Nitropercuten
  • Nitroperlinit
  • Nitroplast
  • Nitroprol
  • Nitropront
  • Nitroprontan
  • NitroQuick
  • NitroQuik
  • Nitrorectal
  • Nitroretard
  • Nitrorex
  • Nitrospan
  • Nitrostabilin
  • Nitrostat
  • Nitrovis
  • Nitrozell retard
  • NK-843
  • NTG
  • NTS
  • Nysconitrine
  • Percutol
  • Percutol Oint.
  • Perganit
  • Perglottal
  • Perlinganit
  • Plastranit
  • Polnitrin
  • Propanetriol trinitrate
  • Ratiopharm
  • RCRA waste number P081
  • Rectiv
  • SK-106N
  • Solution glyceryl trinitrate
  • Soup
  • Spirit of glonoin
  • Spirit of glyceryl trinitrate
  • Spirit of trinitroglycerin
  • Spirits of Nitroglycerin, (1 to 10%)
  • Susadrin
  • Suscard
  • Sustak
  • Sustonit
  • Temponitrin
  • Top-Nitro
  • Transderm Nitro
  • Transderm-N TTS
  • Transderm-Nitro
  • Transderm-Nitro TTS
  • Transiderm-Nitro
  • Tridil
  • Trinalgon
  • Trinipatch
  • Triniplas
  • Trinitrin
  • Trinitrina Erba
  • Trinitrine Simple Laleuf
  • Trinitroglicerina Fabra
  • Trinitroglycerin
  • Trinitroglycerol
  • Trinitrol
  • Trinitrolong
  • Trinitron
  • Trinitrosan
  • Turicard
  • UNII-G59M7S0WS3
  • Vasoglyn
  • Vasolator
  • Vernies
  • Willong

Systematic Names

  • 1,2,3-Propanetriol, 1,2,3-trinitrate
  • 1,2,3-Propanetriol, trinitrate
  • Glycerol trinitrate
  • Nitroglycerin

Superlist Names

  • 1,2,3-Propanetriol, trinitrate
  • Nitroglycerin
  • Nitroglycerin mixture with >2% but not >10% nitroglycerin, by mass, desensitized
  • Nitroglycerin mixture with >2% but not >10% nitroglycerin, by mass, desensitized [UN3319] [Flammable solid]
  • Nitroglycerin, desensitized with not <40% non-volatile water insoluble phlegmatizer, by mass
  • Nitroglycerin, desensitized with not <40% non-volatile water insoluble phlegmatizer, by mass [UN0143] [Explosive 1.1D, Poison]
  • Nitroglycerin, liquid, not desensitized
  • Nitroglycerin, liquid, not desensitized [Forbidden]
  • Nitroglycerin, solution in alcohol with > 5% but not > 10% nitroglycerin
  • Nitroglycerin, solution in alcohol, with >1% but not >10% nitroglycerin
  • Nitroglycerin, solution in alcohol, with >1% but not >10% nitroglycerin [UN0144] [Explosive 1.1D]
  • Nitroglycerin, solution in alcohol, with >1% but not >5% nitroglycerin
  • Nitroglycerin, solution in alcohol, with >1% but not >5% nitroglycerin [UN3064] [Flammable liquid]
  • Nitroglycerin, solution in alcohol, with not >1% nitroglycerin
  • Nitroglycerin, solution in alcohol, with not >1% nitroglycerin [UN1204] [Flammable liquid]
  • Nitroglycerine
  • RCRA waste no. P081
  • UN0143
  • UN0144
  • UN1204
  • UN3064
  • UN3319

Mixture Names

  • SDM No. 17
  • SDM No. 27

Registry Numbers

CAS Registry Number

  • 55-63-0

FDA UNII

  • G59M7S0WS3

Other Registry Numbers

  • 100292-13-5
  • 105469-31-6
  • 80066-48-4
  • 8013-23-8
  • 9010-02-0

System Generated Number

  • 0000055630

Structure Descriptors

InChI

1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2

InChIKey

SNIOPGDIGTZGOP-UHFFFAOYSA-N

Smiles

C(CO[N+](=O)[O-])(CO[N+](=O)[O-])O[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo subcutaneous 150mg/kg (150mg/kg) BLOOD: NORMOCYTIC ANEMIA

LIVER: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 200, Pg. 271, 1942.
dog LD50 intravenous 19mg/kg (19mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE
Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 629, 1981.
guinea pig LD50 oral 1450mg/kg (1450mg/kg) CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 180, 1999.
mammal (species unspecified) LD50 unreported 230mg/kg (230mg/kg)   French Demande Patent Document. Vol. #2454807,
man TDLo intravenous 51429ug/kg/2D (51.429mg/kg) SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BRAIN AND COVERINGS: ENCEPHALITIS
Annals of Internal Medicine. Vol. 101, Pg. 500, 1984.
mouse LD50 intraperitoneal 104mg/kg (104mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 90, 1982.
mouse LD50 intravenous 10600ug/kg (10.6mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 90, 1982.
mouse LD50 oral 115mg/kg (115mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3649, 1985.
mouse LD50 skin > 35200ug/kg (35.2mg/kg)   Drugs in Japan Vol. -, Pg. 786, 1990.
mouse LD50 subcutaneous 110mg/kg (110mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3649, 1985.
rabbit LD50 intraperitoneal 189mg/kg (189mg/kg)   Drugs in Japan Vol. -, Pg. 786, 1990.
rabbit LD50 intravenous 45mg/kg (45mg/kg)   Drugs in Japan Vol. 6, Pg. 547, 1982.
rabbit LD50 oral 1607mg/kg (1607mg/kg)   Drugs in Japan Vol. -, Pg. 786, 1990.
rabbit LD50 skin > 280mg/kg (280mg/kg)   Drugs in Japan Vol. -, Pg. 786, 1990.
rabbit LDLo subcutaneous 400mg/kg (400mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 200, Pg. 271, 1942.
rat LD50 intraperitoneal 102mg/kg (102mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 90, 1982.
rat LD50 intraperitoneal 102mg/kg (102mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 90, 1982.
rat LD50 intravenous 23200ug/kg (23.2mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
JAT, Journal of Applied Toxicology. Vol. 3, Pg. 161, 1983.
rat LD50 oral 105mg/kg (105mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3649, 1985.
rat LD50 skin > 29200ug/kg (29.2mg/kg)   Drugs in Japan Vol. -, Pg. 786, 1990.
rat LD50 subcutaneous 94mg/kg (94mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3649, 1985.
women TDLo oral 8ug/kg (0.008mg/kg) CARDIAC: PULSE RATE

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: HEADACHE
American Journal of Emergency Medicine. Vol. 11, Pg. 253, 1993.
women TDLo oral 8ug/kg (0.008mg/kg) CARDIAC: PULSE RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annals of Emergency Medicine. Vol. 23, Pg. 31, 1994.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 13.5 deg C   EXP
Boiling Point 250 deg C   EXP
log P (octanol-water) 1.62 (none)   EXP
Water Solubility 1380 mg/L 20 EXP
Henry's Law Constant 9.87E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.10E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.