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Substance Name: Triprolidine hydrochloride anhydrous
RN: 550-70-9
UNII: NG7A104R3J
InChIKey: WYUYEJNGHIOFOC-NWBUNABESA-N

Note

  • Histamine H1 antagonist used in ALLERGIC RHINITIS; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.

Molecular Formula

  • C19-H22-N2.Cl-H

Molecular Weight

  • 314.858
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Triprolidine hydrochloride anhydrous

Synonyms

  • 295 C 51
  • Actidil
  • Actidilat
  • EINECS 208-985-0
  • Entra
  • Pro-Actidil
  • Pro-Entra
  • Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, monohydrochloride, (E)-
  • trans-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine monohydrochloride
  • Triprolidine HCl
  • Triprolidine hydrochloride
  • UNII-NG7A104R3J
  • Venen

Systematic Names

  • Pyridine, 2-((1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl)-, hydrochloride (1:1)
  • Pyridine, 2-((1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, monohydrochloride
  • Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, monohydrochloride, (E)-
  • Triprolidine hydrochloride

Registry Numbers

CAS Registry Number

  • 550-70-9

FDA UNII

  • NG7A104R3J

Related Registry Number

  • 486-12-4 (Parent)

System Generated Number

  • 0000550709

Molecular Formulas

Molecular Formula

  • C19-H22-N2.Cl-H

Molecular Formula Fragments

  • C19-H22-N2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;

InChIKey

WYUYEJNGHIOFOC-NWBUNABESA-N

Smiles

c1nc(ccc1)C(\c1ccc(cc1)C)=C/CN1CCCC1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 5mg/kg (5mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
British Journal of Pharmacology and Chemotherapy. Vol. 8, Pg. 171, 1953.
mouse LD50 intravenous 21mg/kg (21mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 8, Pg. 171, 1953.
mouse LD50 oral 495mg/kg (495mg/kg)   Drugs in Japan Vol. 6, Pg. 525, 1982.
mouse LD50 subcutaneous 247mg/kg (247mg/kg)   Drugs in Japan Vol. 6, Pg. 525, 1982.
rat LD50 oral 840mg/kg (840mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 375, 1980.