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Substance Name: Propoxycaine hydrochloride [USP]
RN: 550-83-4
UNII: K490D39G46
InChIKey: GITPCGSPKUQZTE-UHFFFAOYSA-N

Note

  • A local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1017)

Molecular Formula

  • C16-H26-N2-O3.Cl-H

Molecular Weight

  • 330.853
 

Classification Codes

  • Anesthetic (Local)
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Propoxycaine hydrochloride [USP]

Synonyms

  • 2-(Diethylamino)ethyl 4-amino-2-propoxybenzoate monohydrochloride
  • 4-Amino-2-propoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride
  • Blockain
  • Blockain Hydrochloride
  • EINECS 208-988-7
  • Pravocaine hydrochloride
  • Propoxycaine HCl
  • Propoxycaine hydrochloride
  • Ravocaine hydrochloride
  • UNII-K490D39G46
  • WIN 3459

Systematic Names

  • Benzoic acid, 4-amino-2-propoxy-, 2-(diethylamino)ethyl ester, monohydrochloride
  • Propoxycaine hydrochloride

Registry Numbers

CAS Registry Number

  • 550-83-4

FDA UNII

  • K490D39G46

System Generated Number

  • 0000550834

Molecular Formulas

Molecular Formula

  • C16-H26-N2-O3.Cl-H

Molecular Formula Fragments

  • C16-H26-N2-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H26N2O3.ClH/c1-4-10-20-15-12-13(17)7-8-14(15)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H

InChIKey

GITPCGSPKUQZTE-UHFFFAOYSA-N

Smiles

c1(c(cc(N)cc1)OCCC)C(OCCN(CC)CC)=O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 7417ug/kg (7.417mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 269, 1958.
mouse LD50 subcutaneous 80mg/kg (80mg/kg)   Annales Pharmaceutiques Francaises. Vol. 40, Pg. 133, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 149 deg C   EXP
log P (octanol-water) 1.530 (none)   EST
Atmospheric OH Rate Constant 2.41E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.