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Substance Name: Naphazoline hydrochloride [USP:JAN]
RN: 550-99-2
UNII: MZ1131787D
InChIKey: DJDFFEBSKJCGHC-UHFFFAOYSA-N

Note

  • An adrenergic vasoconstrictor agent used as a decongestant.

Classification Codes

  • Drug / Therapeutic Agent
  • Pharmaceutic Aid (Tablet and Capsule Diluent)

Molecular Formula

  • C14-H14-N2.Cl-H

Molecular Weight

  • 246.7395
 
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Names and Synonyms

Name of Substance

  • Naphazoline hydrochloride
  • Naphazoline hydrochloride [USP:JAN]

MeSH Heading

  • Naphazoline

Synonyms

  • 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, monohydrochloride
  • 2-(1-Naphthylmethyl)-2-imidazoline hydrochloride
  • 2-(1-Naphthylmethyl)-2-imidazoline monohydrochloride
  • 2-(1-Naphthylmethyl)imidazoline hydrochloride
  • 2-Imidazoline, 2-(1-naphthylmethyl)-, monohydrochloride
  • Albalon
  • Albalon Liquifilm
  • Clera hydrochloride
  • Coldan
  • Comfort Eye Drops
  • Degest-2
  • EINECS 208-989-2
  • HSDB 2174
  • Nafazair
  • Naphazoline chloride
  • Naphazoline HCl
  • Naphazoline hydrochloride
  • Naphazolini chloridum
  • Naphazoliniumchlorid
  • Naphcon
  • Naphcon forte
  • Naphthasolium chloride
  • Naphthylmethylimidazolinhydrochlorid
  • Niazol
  • NSC 35711
  • Opcon
  • Privine hydrochloride
  • Prizole hydrochloride
  • Rhinantin
  • Rhinoperd
  • Rinofug
  • Sanorin
  • Stricylon
  • UNII-MZ1131787D
  • Vasoclear
  • Vasocon

Systematic Names

  • 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, monohydrochloride
  • 2-Imidazoline, 2-(1-naphthylmethyl)-, monohydrochloride
  • Naphazoline hydrochloride

Mixture Names

  • 4-Way Nasal Spray Regular and Menthol
  • Clear Eyes
  • Naphcon-A
  • VasoClear A
  • Vasocon-A

Registry Numbers

CAS Registry Number

  • 550-99-2

FDA UNII

  • MZ1131787D

Other Registry Number

  • 35412-62-5

Related Registry Number

  • 835-31-4 (Parent)

System Generated Number

  • 0000550992

Molecular Formulas

Molecular Formula

  • C14-H14-N2.Cl-H

Molecular Formula Fragments

  • C14-H14-N2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H

InChIKey

DJDFFEBSKJCGHC-UHFFFAOYSA-N

Smiles

c1ccc2c(c1)cccc2CC3=NCCN3.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 2uL/kg (0.002mL/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Japanese Journal of Toxicology. Vol. 9, Pg. 295, 1996.
mouse LD50 intraperitoneal 50mg/kg (50mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 28, Pg. 761, 1993.
mouse LD50 intravenous 16500ug/kg (16.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 341, 1955.
mouse LD50 subcutaneous 170mg/kg (170mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 280, 1946.
rabbit LD50 intramuscular 950ug/kg (0.95mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.
rabbit LD50 intravenous 800ug/kg (0.8mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.
rabbit LD50 oral 50mg/kg (50mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Schweizerische Medizinische Wochenschrift. Vol. 71, Pg. 554, 1941.
rabbit LD50 subcutaneous 4mg/kg (4mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Schweizerische Medizinische Wochenschrift. Vol. 71, Pg. 554, 1941.
rat LD50 intraperitoneal 50mg/kg (50mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.
rat LD50 intravenous 6mg/kg (6mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 341, 1955.
rat LD50 subcutaneous 200mg/kg (200mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Schweizerische Medizinische Wochenschrift. Vol. 71, Pg. 554, 1941.