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Substance Name: Ticlopidine [INN:BAN]
RN: 55142-85-3
UNII: OM90ZUW7M1
InChIKey: PHWBOXQYWZNQIN-UHFFFAOYSA-N

Note

  • An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.

Molecular Formula

  • C14-H14-Cl-N-S

Molecular Weight

  • 263.7906
 

Classification Codes

  • Cardiovascular Agents
  • Cytochrome P-450 CYP2C19 Inhibitors
  • Cytochrome P-450 Enzyme Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Fibrin Modulating Agents
  • Fibrinolytic Agents
  • Hematologic Agents
  • Human Data
  • Neurotransmitter Agents
  • Platelet Aggregation Inhibitors
  • Purinergic Agents
  • Purinergic Antagonists
  • Purinergic P2 Receptor Antagonists
  • Purinergic P2Y Receptor Antagonists

Names and Synonyms

Name of Substance

  • Ticlopidine
  • Ticlopidine [INN:BAN]

MeSH Heading

  • Ticlopidine

Synonyms

  • 5-((2-Chlorophenyl)methyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine
  • BRN 1216802
  • EINECS 259-498-5
  • PCR 5332
  • Ticlopidina
  • Ticlopidina [INN-Spanish]
  • Ticlopidine
  • Ticlopidinum
  • Ticlopidinum [INN-Latin]
  • UNII-OM90ZUW7M1

Systematic Names

  • Thieno(3,2-c)pyridine, 4,5,6,7-tetrahydro-5-((2-chlorophenyl)methyl)-
  • Thieno(3,2-c)pyridine, 5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-
  • Ticlopidine

Registry Numbers

CAS Registry Number

  • 55142-85-3

FDA UNII

  • OM90ZUW7M1

System Generated Number

  • 0055142853

Structure Descriptors

InChI

1S/C14H14ClNS/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14/h1-4,6,8H,5,7,9-10H2

InChIKey

PHWBOXQYWZNQIN-UHFFFAOYSA-N

Smiles

c12c(CCN(C1)Cc1c(cccc1)Cl)scc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man LDLo oral 336mg/kg/47D- (336mg/kg) BLOOD: THROMBOCYTOPENIA

BLOOD: AGRANULOCYTOSIS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annals of Pharmacotherpy. Vol. 28, Pg. 1236, 1994.
man TDLo oral 350mg/kg/7W-I (350mg/kg) BLOOD: AGRANULOCYTOSIS Postgraduate Medical Journal. Vol. 74, Pg. 126, 1998.
man TDLo oral 429mg/kg/6OD- (429mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Lancet. Vol. 1, Pg. 407, 1984.
monkey LD50 intraperitoneal 500mg/kg (500mg/kg) LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983.
monkey LD50 oral > 6gm/kg (6000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983.
mouse LD50 intraperitoneal 1250mg/kg (1250mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983.
mouse LD50 intravenous 88mg/kg (88mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983.
mouse LD50 oral 600mg/kg (600mg/kg) LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983.
rat LD50 intraperitoneal > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983.
rat LD50 intravenous 70mg/kg (70mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983.
rat LD50 oral 1780mg/kg (1780mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983.
women TDLo oral 100mg/kg/10D- (100mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

BLOOD: EOSINOPHILIA

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
American Journal of Kidney Diseases. Vol. 25, Pg. 934, 1995.
women TDLo oral 350mg/kg/5W-I (350mg/kg)   Annals of Pharmacotherpy. Vol. 33, Pg. 939, 1999.
women TDLo oral 350mg/kg/5W-I (350mg/kg)   Annals of Pharmacotherpy. Vol. 33, Pg. 939, 1999.
women TDLo oral 350mg/kg/5W-I (350mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED Annals of Pharmacotherpy. Vol. 33, Pg. 939, 1999.
women TDLo oral 600mg/kg/60D- (600mg/kg) BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE

BLOOD: APLASTIC ANEMIA
Israel Journal of Medical Sciences. Vol. 31, Pg. 444, 1995.