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Substance Name: Ticlopidine [INN:BAN]
RN: 55142-85-3
UNII: OM90ZUW7M1
InChIKey: PHWBOXQYWZNQIN-UHFFFAOYSA-N
Note
- An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
Molecular Formula
- C14-H14-Cl-N-S
Molecular Weight
- 263.7906
Classification Codes
- Cardiovascular Agents
- Cytochrome P-450 CYP2C19 Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Fibrin Modulating Agents
- Fibrinolytic Agents
- Hematologic Agents
- Human Data
- Metabolic Side Effects of Drugs and Substances
- Neurotransmitter Agents
- Platelet Aggregation Inhibitors
- Purinergic Antagonists
- Purinergic P2 Receptor Antagonists
- Purinergic P2Y Receptor Antagonists
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Names and Synonyms
Name of Substance
- Ticlopidine
- Ticlopidine [INN:BAN]
MeSH Heading
- Ticlopidine
Synonyms
- 5-((2-Chlorophenyl)methyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine
- BRN 1216802
- EINECS 259-498-5
- PCR 5332
- Ticlopidina
- Ticlopidina [INN-Spanish]
- Ticlopidine
- Ticlopidinum
- Ticlopidinum [INN-Latin]
- UNII-OM90ZUW7M1
Systematic Names
- Thieno(3,2-c)pyridine, 4,5,6,7-tetrahydro-5-((2-chlorophenyl)methyl)-
- Thieno(3,2-c)pyridine, 5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-
- Ticlopidine
Registry Numbers
CAS Registry Number
- 55142-85-3
FDA UNII
- OM90ZUW7M1
System Generated Number
- 0055142853
Structure Descriptors
InChI
InChI=1S/C14H14ClNS/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14/h1-4,6,8H,5,7,9-10H2InChIKey
PHWBOXQYWZNQIN-UHFFFAOYSA-NSmiles
Clc1ccccc1CN2CCc3sccc3C2Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | LDLo | oral | 336mg/kg/47D- (336mg/kg) | BLOOD: THROMBOCYTOPENIA BLOOD: AGRANULOCYTOSIS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Annals of Pharmacotherpy. Vol. 28, Pg. 1236, 1994. |
man | TDLo | oral | 350mg/kg/7W-I (350mg/kg) | BLOOD: AGRANULOCYTOSIS | Postgraduate Medical Journal. Vol. 74, Pg. 126, 1998. |
man | TDLo | oral | 429mg/kg/6OD- (429mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Lancet. Vol. 1, Pg. 407, 1984. |
monkey | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
monkey | LD50 | oral | > 6gm/kg (6000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING SKIN AND APPENDAGES (SKIN): HAIR: OTHER | New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
mouse | LD50 | intraperitoneal | 1250mg/kg (1250mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING | New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
mouse | LD50 | intravenous | 88mg/kg (88mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING SKIN AND APPENDAGES (SKIN): HAIR: OTHER | New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
mouse | LD50 | oral | 600mg/kg (600mg/kg) | LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): HAIR: OTHER | New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
rat | LD50 | intraperitoneal | > 5gm/kg (5000mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING | New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
rat | LD50 | intravenous | 70mg/kg (70mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING | New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
rat | LD50 | oral | 1780mg/kg (1780mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
women | TDLo | oral | 100mg/kg/10D- (100mg/kg) | KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED BLOOD: EOSINOPHILIA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | American Journal of Kidney Diseases. Vol. 25, Pg. 934, 1995. |
women | TDLo | oral | 350mg/kg/5W-I (350mg/kg) | Annals of Pharmacotherpy. Vol. 33, Pg. 939, 1999. | |
women | TDLo | oral | 350mg/kg/5W-I (350mg/kg) | Annals of Pharmacotherpy. Vol. 33, Pg. 939, 1999. | |
women | TDLo | oral | 350mg/kg/5W-I (350mg/kg) | LIVER: LIVER FUNCTION TESTS IMPAIRED | Annals of Pharmacotherpy. Vol. 33, Pg. 939, 1999. |
women | TDLo | oral | 600mg/kg/60D- (600mg/kg) | BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE BLOOD: APLASTIC ANEMIA | Israel Journal of Medical Sciences. Vol. 31, Pg. 444, 1995. |