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Substance Name: Praziquantel [USAN:USP:INN:BAN:JAN]
RN: 55268-74-1
UNII: 6490C9U457
InChIKey: FSVJFNAIGNNGKK-UHFFFAOYSA-N

Notes

  • An anthelmintic used in most schistosome and many cestode infestations.
  • Russian drug.

Molecular Formula

  • C19-H24-N2-O2

Molecular Weight

  • 312.411
 

Classification Codes

  • Anthelmintic (Veterinary)
  • Anthelmintics
  • Anti-Infective Agents
  • Antiparasitic Agents
  • Drug / Therapeutic Agent
  • Mutation Data

Names and Synonyms

Name of Substance

  • Azinox
  • Praziquantel
  • Praziquantel [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Praziquantel

Synonyms

  • 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin-4-one
  • 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-
  • 5-24-03-00361 (Beilstein Handbook Reference)
  • Azinox
  • Biltricide
  • BRN 0761557
  • CCRIS 4114
  • Cutter Tape Tabs
  • Distocide
  • Droncit
  • EINECS 259-559-6
  • Embay 8440
  • NSC 757285
  • Prazinon
  • Praziquantel
  • Praziquantelum
  • Praziquantelum [INN-Latin]
  • Pyquiton
  • UNII-6490C9U457

Systematic Names

  • 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-
  • Azinox
  • Praziquantel

Mixture Names

  • Drontal
  • Drontal Plus
  • Profender
  • Vercom

Registry Numbers

CAS Registry Number

  • 55268-74-1

FDA UNII

  • 6490C9U457

Other Registry Number

  • 135526-78-2

System Generated Number

  • 0055268741

Structure Descriptors

InChI

InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2

InChIKey

FSVJFNAIGNNGKK-UHFFFAOYSA-N

Smiles

O=C(C1CCCCC1)N2CC3N(CCc4ccccc34)C(=O)C2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 200mg/kg (200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981.
mouse LD50 intramuscular > 2gm/kg (2000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981.
mouse LD50 intraperitoneal 376mg/kg (376mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989.
mouse LD50 oral 2454mg/kg (2454mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981.
mouse LD50 subcutaneous 7172mg/kg (7172mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981.
rabbit LD50 oral 1050mg/kg (1050mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981.
rat LD50 intramuscular > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 965, 1990.
rat LD50 intraperitoneal 586mg/kg (586mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989.
rat LD50 oral 2840mg/kg (2840mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981.
rat LD50 subcutaneous > 16gm/kg (16000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 136 deg C   EXP
log P (octanol-water) 2.420 (none)   EST
Water Solubility 400 mg/L   EXP
Atmospheric OH Rate Constant 6.55E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.