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Substance Name: Praziquantel [USAN:USP:INN:BAN:JAN]
RN: 55268-74-1
UNII: 6490C9U457
InChIKey: FSVJFNAIGNNGKK-UHFFFAOYSA-N
Note
- An anthelmintic used in most schistosome and many cestode infestations.
Molecular Formula
- C19-H24-N2-O2
Molecular Weight
- 312.411
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anthelmintic (Veterinary)
- Anthelmintics
- Anti-Infective Agents
- Antiparasitic Agents
- Drug / Therapeutic Agent
- Mutation Data
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Names and Synonyms
Name of Substance
- Praziquantel
- Praziquantel [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Praziquantel
Synonyms
- 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin-4-one
- 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-
- 5-24-03-00361 (Beilstein Handbook Reference)
- Azinox
- Biltricide
- BRN 0761557
- CCRIS 4114
- Cutter Tape Tabs
- Distocide
- Droncit
- EINECS 259-559-6
- Embay 8440
- Prazinon
- Praziquantel
- Praziquantelum
- Praziquantelum [INN-Latin]
- Pyquiton
- UNII-6490C9U457
Systematic Names
- 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-
- Praziquantel
Mixture Names
- Drontal
- Drontal Plus
- Profender
- Vercom
Registry Numbers
CAS Registry Number
- 55268-74-1
FDA UNII
- 6490C9U457
System Generated Number
- 0055268741
Structure Descriptors
InChI
InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2InChIKey
FSVJFNAIGNNGKK-UHFFFAOYSA-NSmiles
O=C(C1CCCCC1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | > 200mg/kg (200mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981. | |
| mouse | LD50 | intramuscular | > 2gm/kg (2000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981. | |
| mouse | LD50 | intraperitoneal | 376mg/kg (376mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989. | |
| mouse | LD50 | oral | 2454mg/kg (2454mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981. | |
| mouse | LD50 | subcutaneous | 7172mg/kg (7172mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981. | |
| rabbit | LD50 | oral | 1050mg/kg (1050mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981. | |
| rat | LD50 | intramuscular | > 2gm/kg (2000mg/kg) | Drugs in Japan Vol. -, Pg. 965, 1990. | |
| rat | LD50 | intraperitoneal | 586mg/kg (586mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989. | |
| rat | LD50 | oral | 2840mg/kg (2840mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981. | |
| rat | LD50 | subcutaneous | > 16gm/kg (16000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 136 | deg C | EXP | |
| log P (octanol-water) | 2.420 | (none) | EST | |
| Water Solubility | 400 | mg/L | EXP | |
| Atmospheric OH Rate Constant | 6.55E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.