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Substance Name: Muzolimine [USAN:INN:BAN]
RN: 55294-15-0
UNII: 07Z36289ZX
InChIKey: RLWRMIYXDPXIEX-UHFFFAOYSA-N

Note

  • A pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects.

Molecular Formula

  • C11-H11-Cl2-N3-O

Molecular Weight

  • 272.1339
 

Classification Codes

  • Antihypertensive
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Diuretic
  • Diuretics
  • Drug / Therapeutic Agent
  • Natriuretic Agents
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Names and Synonyms

Name of Substance

  • Muzolimine
  • Muzolimine [USAN:INN:BAN]

MeSH Heading

  • Muzolimine

Synonyms

  • 3-Amino-1-(3,4-dichloro-alpha-methylbenzyl)-2-pyrazolin-5-one
  • 3-Amino-1-(3,4-dichloro-alpha-methylbenzyl)-4,5-dihydro-5-pyrazolon
  • 3H-Pyrazol-3-one, 2,4-dihydro-5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-
  • 3H-Pyrazol-3-one, 5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-2,4-dihydro-
  • 5-Amino-2-(1-(3,4-dichlorophenyl)-ethyl)-2,4-dihydro-3H-pyrazol-3-one
  • Bay g 2821
  • BRN 0660881
  • Edrul
  • EINECS 259-573-2
  • Muzolimina
  • Muzolimina [INN-Spanish]
  • Muzolimina [Spanish]
  • Muzolimine
  • Muzoliminum
  • Muzoliminum [INN-Latin]
  • UNII-07Z36289ZX

Systematic Names

  • 3H-Pyrazol-3-one, 5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-2,4-dihydro-
  • Muzolimine

Registry Numbers

CAS Registry Number

  • 55294-15-0

FDA UNII

  • 07Z36289ZX

Other Registry Number

  • 37296-93-8

System Generated Number

  • 0055294150

Structure Descriptors

InChI

1S/C11H11Cl2N3O/c1-6(16-11(17)5-10(14)15-16)7-2-3-8(12)9(13)4-7/h2-4,6H,5H2,1H3,(H2,14,15)

InChIKey

RLWRMIYXDPXIEX-UHFFFAOYSA-N

Smiles

CC(N1N=C(N)CC1=O)c2ccc(Cl)c(Cl)c2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 200mg/kg (200mg/kg)   Clinical Nephrology. Vol. 19(Suppl,
dog LD50 oral 2gm/kg (2000mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

BEHAVIORAL: FLUID INTAKE
Current Medical Research and Opinion. Vol. 4, Pg. 716, 1977.
mouse LD50 intravenous 310mg/kg (310mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Clinical Nephrology. Vol. 19(Suppl,
mouse LD50 oral 1794mg/kg (1794mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Current Medical Research and Opinion. Vol. 4, Pg. 716, 1977.
rabbit LD50 oral 1250mg/kg (1250mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Current Medical Research and Opinion. Vol. 4, Pg. 716, 1977.
rat LD50 intravenous 221mg/kg (221mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Clinical Nephrology. Vol. 19(Suppl,
rat LD50 oral 1559mg/kg (1559mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Current Medical Research and Opinion. Vol. 4, Pg. 716, 1977.