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Substance Name: Butethamine hydrochloride [NF]
RN: 553-68-4
UNII: 0M63DKI91K
InChIKey: ARKDNMZXRXKLOV-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C13-H20-N2-O2.Cl-H

Molecular Weight

  • 272.7739
 
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Names and Synonyms

Name of Substance

  • Butethamine hydrochloride [NF]

Synonyms

  • 2-(Isobutylamino)ethyl p-aminobenzoate hydrochloride
  • 2-Isobutylaminoethanol hydrochloric acid salt, p-aminobenzoic acid ester
  • Benzoic acid, p-amino-, 2-(isobutylamino)ethyl ester, hydrochloride
  • Butethamine HCl
  • Butethamine hydrochloride
  • Ibylcaine
  • Ibylcaine chloride
  • Ibylcaine hydrochloride
  • Monocaine
  • Monocaine hydrochloride
  • NSC 10821
  • p-Aminobenzoic acid 2-(isobutylamino)ethyl ester hydrochloride
  • p-Aminobenzoic acid ester of 2-isobutylaminoethanol hydrochloric acid salt
  • UNII-0M63DKI91K

Systematic Names

  • Ethanol, 2-((2-methylpropyl)amino)-, 4-aminobenzoate (ester), monohydrochloride (9CI)
  • Ethanol, 2-(isobutylamino)-, p-aminobenzoate (ester), monohydrochloride

Registry Numbers

CAS Registry Number

  • 553-68-4

FDA UNII

  • 0M63DKI91K

System Generated Number

  • 0000553684

Molecular Formulas

Molecular Formula

  • C13-H20-N2-O2.Cl-H

Molecular Formula Fragments

  • C13-H20-N2-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C13H20N2O2.ClH/c1-10(2)9-15-7-8-17-13(16)11-3-5-12(14)6-4-11;/h3-6,10,15H,7-9,14H2,1-2H3;1H

InChIKey

ARKDNMZXRXKLOV-UHFFFAOYSA-N

Smiles

Cl.CC(C)CNCCOC(=O)c1ccc(N)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo subcutaneous 215mg/kg (215mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 62, Pg. 69, 1938.
mouse LD50 intraperitoneal 169mg/kg (169mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 483, 1958.
mouse LD50 intravenous 36mg/kg (36mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 483, 1958.
mouse LD50 subcutaneous 449mg/kg (449mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Anesthesiology. Vol. 3, Pg. 398, 1942.
rabbit LDLo intravenous 30mg/kg (30mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 62, Pg. 69, 1938.
rat LD50 intraperitoneal 182mg/kg (182mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Anesthesiology. Vol. 3, Pg. 398, 1942.
rat LD50 intravenous 28mg/kg (28mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Anesthesiology. Vol. 3, Pg. 398, 1942.