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Substance Name: Beclomethasone dipropionate [USAN:USP]
RN: 5534-09-8
UNII: 5B307S63B2
InChIKey: KUVIULQEHSCUHY-XYWKZLDCSA-N

Note

  • An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.

Molecular Formula

  • C28-H37-Cl-O7

Molecular Weight

  • 521.0463
 

Classification Codes

  • Anti-Inflammatory
  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Hormone
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Beclomethasone dipropionate
  • Beclomethasone dipropionate [USAN:USP]

Synonyms

  • 9-Chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate
  • Aerobec
  • Alanase
  • Aldecin
  • Aldecina
  • Aldecine
  • Atomase
  • Beclacin
  • Beclate
  • Beclazone
  • Beclazone 250
  • Beclocort Nasel
  • Becloforte
  • Beclomet
  • Beclomet Nasal
  • Beclometasone 17,21-dipropionate
  • Beclometasone dipropionate
  • Beclometasone dipropionato
  • Beclomethasone dipropionate
  • Beclorhinol
  • Becloturmant
  • Beclovent
  • Beconase
  • Beconase AQ
  • Becotide
  • Benconase
  • Clenil
  • Clenil-A
  • EINECS 226-886-0
  • Entyderma
  • Inalone O
  • Inalone R
  • Korbutone
  • KW-053
  • Menaderm
  • Propaderm
  • Propaderm Forte
  • QNASL
  • QVAR
  • Qvar 40
  • Qvar 80
  • Respocort
  • Rhino Clenil
  • Rhinosol
  • Rino-clenil
  • Sanasthmax
  • Sanasthmyl
  • Sch 18020W
  • Spir
  • Turbinal
  • UNII-5B307S63B2
  • Vancenase
  • Vanceril
  • Vanceril Double Strength
  • Ventolair
  • Viarox

Systematic Names

  • 9-Chloro-11beta-hydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate
  • Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11beta,16beta)-
  • Pregna-1,4-diene-3,20-dione, 9-chloro-16-beta-methyl-11-beta,17,21-trihydroxy-, 17,21-dipropionate

Superlist Name

  • Beclomethasone dipropionate

Registry Numbers

CAS Registry Number

  • 5534-09-8

FDA UNII

  • 5B307S63B2

Other Registry Number

  • 34135-07-4

System Generated Number

  • 0005534098

Structure Descriptors

InChI

1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

InChIKey

KUVIULQEHSCUHY-XYWKZLDCSA-N

Smiles

C=1C(=O)C=C2[C@@](C1)(C)[C@@]1([C@@H](CC2)[C@H]2[C@](C)(C[C@@H]1O)[C@@](OC(CC)=O)(C(COC(CC)=O)=O)[C@H](C)C2)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 746, 1982.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 746, 1982.
mouse LDLo intraperitoneal 2gm/kg (2000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1037, 1971.
rabbit LD subcutaneous > 750mg/kg (750mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LIVER: OTHER CHANGES
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 19, Pg. 65, 1970.
rat LC50 inhalation > 51600ug/m3/2 (51.6mg/m3) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 2, Pg. 97, 1976.
rat LD50 intraperitoneal > 3gm/kg (3000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 863, 1976.
rat LD50 oral > 3750mg/kg (3750mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 863, 1976.
rat LD50 subcutaneous > 1500mg/kg (1500mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 863, 1976.