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Substance Name: Glucosulfone [INN]
RN: 554-18-7
UNII: I6RLN7D44F
InChIKey: NLLGJEMIZSAJFN-AAFOHLTDSA-L

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H36-N2-O18-S3.2Na

Molecular Weight

  • 780.7066
 
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Names and Synonyms

Name of Substance

  • Glucosulfone sodium
  • Glucosulfone [INN]
  • Sodium glucosulfone [USP]

Synonyms

  • 1,1'-(Sulfonylbis(4,1-phenyleneimino))bis(1-deoxy-1-sulfo-D-glucitol) disodium salt
  • 4,4'-Diamino-diphenyl-sulfon-di-D-glucosidsulfonat dinatrium
  • 4,4'-Diamino-diphenyl-sulfon-di-D-glucosidsulfonat dinatrium [German]
  • 501 P
  • 501 Siegfried
  • Aceprosol
  • Angeli sulfone
  • Angeli's sulfone
  • Disodium p,p'-diaminodiphenylsulfone-N,N'-diglucose sulfonate
  • EINECS 209-064-6
  • Glucosulfone
  • Glucosulfone (VAN)
  • Glucosulfone sodique
  • Glucosulfone sodium
  • NSC 36701
  • NSC 512486
  • p,p'-Diaminodiphenylsulfone-N,N'-di(dextrose sodium sulfonate)
  • p,p'-Sulfonyldianiline N,N'-diglucoside disodium disulfonate
  • p,p'-Sulfonyldianiline-N,N'-di-D-glucose sodium bisulfite
  • Promanide
  • Promin
  • Promin sodium
  • Protomin
  • S. N. 166
  • SN-166
  • SN-166 [as the sodium salt]
  • Sodium glucosulfone
  • Solfone
  • Solfone (VAN)
  • Sulfona P
  • Tasmin
  • UNII-I6RLN7D44F

Systematic Names

  • 4,4'-Diaminophenylsulfone-N,N-di(dextrose sodium sulfonate)
  • D-Glucitol, 1,1'-(sulfonylbis(4,1-phenyleneimino))bis(1-deoxy-1-sulfo-, disodium salt (9CI)
  • Glucosulfone
  • Glucosulfone, disodium salt

Registry Numbers

CAS Registry Number

  • 554-18-7

FDA UNII

  • I6RLN7D44F

Related Registry Number

  • 551-89-3 (Parent)

System Generated Number

  • 0000554187

Molecular Formulas

Molecular Formula

  • C24-H36-N2-O18-S3.2Na

Molecular Formula Fragments

  • C24-H36-N2-O18-S3
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C24H36N2O18S3.2Na/c27-9-15(29)17(31)19(33)21(35)23(46(39,40)41)25-11-1-5-13(6-2-11)45(37,38)14-7-3-12(4-8-14)26-24(47(42,43)44)22(36)20(34)18(32)16(30)10-28;;/h1-8,15-36H,9-10H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2/t15-,16-,17-,18-,19+,20+,21-,22-,23?,24?;;/m1../s1

InChIKey

NLLGJEMIZSAJFN-AAFOHLTDSA-L

Smiles

[Na+].[Na+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(Nc1ccc(cc1)S(=O)(=O)c2ccc(NC([C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)S(=O)(=O)[O-])cc2)S(=O)(=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 5250mg/kg (5250mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 48, Pg. 363, 1952.
mouse LD50 oral 3930mg/kg (3930mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 48, Pg. 363, 1952.
mouse LD50 subcutaneous 6500mg/kg (6500mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 48, Pg. 363, 1952.
rat LD50 intravenous 3gm/kg (3000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955.
rat LD50 oral 3gm/kg (3000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -9.750 (none)   EST
Atmospheric OH Rate Constant 1.54E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.