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Substance Name: alpha-Methyldopa
RN: 555-29-3
InChIKey: CJCSPKMFHVPWAR-UHFFFAOYSA-N

Note

  • An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C10-H13-N-O4

Molecular Weight

  • 211.2157
 
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Names and Synonyms

Results Name

  • alpha-Methyldopa

Synonyms

  • (+-)-alpha-Methyldopa
  • 3-Hydroxy-alpha-methyl-DL-tyrosine
  • DL-alpha-Methyl DOPA
  • EINECS 209-088-7
  • Metholes
  • Mulfasin
  • racemic alpha-Methyldopa

Systematic Names

  • 3-Hydroxy-alpha-methyl-DL-tyrosine
  • Alanine, 3-(3,4-dihydroxyphenyl)-2-methyl-, DL-
  • DL-Tyrosine, 3-hydroxy-alpha-methyl- (9CI)

Registry Numbers

CAS Registry Number

  • 555-29-3

System Generated Number

  • 0000555293

Structure Descriptors

InChI

1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)

InChIKey

CJCSPKMFHVPWAR-UHFFFAOYSA-N

Smiles

CC(Cc1ccc(c(c1)O)O)(C(=O)O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1317mg/kg (1317mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"
Journal of Medicinal Chemistry. Vol. 23, Pg. 1318, 1980.
mouse LD50 intravenous 1760mg/kg (1760mg/kg)   National Toxicology Program Technical Report Series. Vol. NTP-TR-348, Pg. 1989,
mouse LD50 oral 5370mg/kg (5370mg/kg)   National Toxicology Program Technical Report Series. Vol. NTP-TR-348, Pg. 1989,
rat LD50 intraperitoneal 430mg/kg (430mg/kg)   National Toxicology Program Technical Report Series. Vol. NTP-TR-348, Pg. 1989,
rat LD50 oral 5710mg/kg (5710mg/kg)   National Toxicology Program Technical Report Series. Vol. NTP-TR-348, Pg. 1989,