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Substance Name: Nifuradene [USAN:INN]
RN: 555-84-0
UNII: 2VX65207DR
InChIKey: VSVAVMVWTLLTCH-BJMVGYQFSA-N

Molecular Formula

  • C8-H8-N4-O4

Molecular Weight

  • 224.175
 

Classification Codes

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
  • Mutation Data
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 2B
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Names and Synonyms

Name of Substance

  • (1-(5-Nitro-2-furanyl)methyleneamino)imidazolin-2-one
  • Nifuradene [USAN:INN]

Synonyms

  • 1-((5-Nitrofurfurilidene)amino)-2-imidazolidinone
  • 1-((5-Nitrofurfurylidene)amino)-2-imidazolidinone
  • 2-Imidazolidinone, 1-(((5-nitro-2-furanyl)methylene)amino)-
  • 2-Imidazolidinone, 1-(5-nitrofurfurylideneamino)-
  • 5-24-01-00157 (Beilstein Handbook Reference)
  • BRN 0384793
  • CCRIS 445
  • N-(5-Nitro-2-furfurylidene)-1-amino-2-imidazolidone
  • N-(5-Nitro-2-furfurylideneamino)-2-imidazoaidinone
  • NF 246
  • NF-246
  • Nifuraden
  • Nifuradene
  • Nifuradeno
  • Nifuradeno [INN-Spanish]
  • Nifuradenum
  • Nifuradenum [INN-Latin]
  • Nifuradine
  • NSC 6470
  • NSC-6470
  • Oxafuradene
  • Oxafurandene
  • Oxifuradene
  • Oxyfuradene
  • Renafur
  • UNII-2VX65207DR

Systematic Names

  • 1-((5-Nitrofurfurylidene)amino)-2-imidazolidinone
  • 2-Imidazolidinone, 1-(((5-nitro-2-furanyl)methylene)amino)-
  • 2-Imidazolidinone, 1-((5-nitrofurfurylidene)amino)-

Superlist Names

  • 1-((5-Nitrofurfurylidene)amino)-2-imidazolidinone
  • 2-Imidazolidinone, 1-(((5-nitro-2-furanyl)methylene)amino)-

Registry Numbers

CAS Registry Number

  • 555-84-0

FDA UNII

  • 2VX65207DR

System Generated Number

  • 0000555840

Structure Descriptors

InChI

1S/C8H8N4O4/c13-8-9-3-4-11(8)10-5-6-1-2-7(16-6)12(14)15/h1-2,5H,3-4H2,(H,9,13)/b10-5+

InChIKey

VSVAVMVWTLLTCH-BJMVGYQFSA-N

Smiles

c1(oc([N+](=O)[O-])cc1)\C=N\N1C(NCC1)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1gm/kg (1000mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Journal of Pharmacy and Pharmacology. Vol. 16, Pg. 663, 1964.
mouse LD50 oral > 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ANTIPSYCHOTIC

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Journal of Pharmacy and Pharmacology. Vol. 16, Pg. 663, 1964.
rabbit LD50 oral 538mg/kg (538mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 oral 1681mg/kg (1681mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 262 dec deg C   EXP
log P (octanol-water) 0.240 (none)   EST
Water Solubility 98.5 mg/L   EXP
Atmospheric OH Rate Constant 2.20E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.