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Substance Name: Dexamethasone dipropionate [USAN]
RN: 55541-30-5
UNII: K3UKR54YXW
InChIKey: CIWBQSYVNNPZIQ-PKWREOPISA-N

Note

  • See also record for betamethasone-17,21-dipropionate.

Molecular Formula

  • C28-H37-F-O7

Molecular Weight

  • 504.5913
 

Classification Codes

  • Anti-Inflammatory (Steroid)
  • Hormone
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Dexamethasone dipropionate
  • Dexamethasone dipropionate [USAN]

Synonyms

  • 9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate
  • Dexamethasone 17,21-dipropionate
  • Dexamethasone dipropionate
  • EINECS 259-699-8
  • Methaderm
  • ST12
  • THS-101
  • UNII-K3UKR54YXW

Systematic Names

  • 9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate)
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, 17,21-dipropionate
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11beta,16alpha)-

Registry Numbers

CAS Registry Number

  • 55541-30-5

FDA UNII

  • K3UKR54YXW

System Generated Number

  • 0055541305

Structure Descriptors

InChI

1S/C28H37FO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19+,20+,21+,25+,26+,27+,28+/m1/s1

InChIKey

CIWBQSYVNNPZIQ-PKWREOPISA-N

Smiles

CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 276mg/kg (276mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 474, 1987.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 474, 1987.
mouse LD50 subcutaneous 183mg/kg (183mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 474, 1987.
rabbit LD50 subcutaneous 7600ug/kg (7.6mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984.
rat LD50 intraperitoneal 36500ug/kg (36.5mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984.
rat LD50 subcutaneous 26mg/kg (26mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984.
rat LDLo oral 4gm/kg (4000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984.