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Substance Name: 2-(Hydroxyethyl)-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran
RN: 55636-92-5
InChIKey: SOBIXRUSPZTLPQ-UHFFFAOYSA-N

Note

  • Befunolol metabolite.

Molecular Formula

  • C16-H23-N-O4

Molecular Weight

  • 293.361
 
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Names and Synonyms

Name of Substance

  • 2-(Hydroxyethyl)-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran

Synonyms

  • 2-(1-Hydroxyethyl)-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran
  • BRN 3617665

Systematic Name

  • 2-Benzofuranmethanol, 7-(2-hydroxy-3-(isopropylamino)propoxy)-alpha-methyl-

Registry Numbers

CAS Registry Number

  • 55636-92-5

System Generated Number

  • 0055636925

Structure Descriptors

InChI

1S/C16H23NO4/c1-10(2)17-8-13(19)9-20-14-6-4-5-12-7-15(11(3)18)21-16(12)14/h4-7,10-11,13,17-19H,8-9H2,1-3H3

InChIKey

SOBIXRUSPZTLPQ-UHFFFAOYSA-N

Smiles

c12c(cc(o2)[C@@H](C)O)cccc1OC[C@@H](CNC(C)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 179mg/kg (179mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 4138, 1979.
mouse LD50 intravenous 68500ug/kg (68.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 4138, 1979.
mouse LD50 oral 1275mg/kg (1275mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 4138, 1979.
mouse LD50 subcutaneous 640mg/kg (640mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 4138, 1979.
rat LD50 intraperitoneal 185mg/kg (185mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 4138, 1979.
rat LD50 oral 2130mg/kg (2130mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 4138, 1979.
rat LD50 subcutaneous 540mg/kg (540mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 4138, 1979.