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Substance Name: Butobendine hydrochloride
RN: 55769-64-7
UNII: 3OXO5I6B0G
InChIKey: NNSPSTCLUNWYSE-WLKYSPGFSA-N

Note

  • Craviten is tradename.

Molecular Formula

  • C32-H48-N2-O10.2Cl-H

Molecular Weight

  • 693.657
 

Classification Codes

  • Anti-Arrhythmia Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Butobendine hydrochloride

Synonyms

  • Butobendine dihydrochloride
  • Butobendine HCl
  • Craviten
  • M 71
  • M-71
  • UNII-3OXO5I6B0G

Systematic Name

  • Benzoic acid, 3,4,5-trimethoxy-, 1,2-ethanediylbis(methylimino)(2-ethyl-2,1-ethanediyl) ester, dihydrochloride, (S-(R*,R*))-

Registry Numbers

CAS Registry Number

  • 55769-64-7

FDA UNII

  • 3OXO5I6B0G

System Generated Number

  • 0055769647

Molecular Formulas

Molecular Formula

  • C32-H48-N2-O10.2Cl-H

Molecular Formula Fragments

  • C32-H48-N2-O10
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C32H48N2O10.2ClH/c1-11-23(19-43-31(35)21-15-25(37-5)29(41-9)26(16-21)38-6)33(3)13-14-34(4)24(12-2)20-44-32(36)22-17-27(39-7)30(42-10)28(18-22)40-8;;/h15-18,23-24H,11-14,19-20H2,1-10H3;2*1H/t23-,24-;;/m0../s1

InChIKey

NNSPSTCLUNWYSE-WLKYSPGFSA-N

Smiles

c1(c(cc(cc1OC)C(=O)OC[C@@H]([NH+](CC[NH+]([C@H](COC(=O)c1cc(c(c(c1)OC)OC)OC)CC)C)C)CC)OC)OC.[Cl-].[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 2500ug/kg (2.5mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 32, Pg. 833, 1980.
mouse LD50 intraperitoneal 550mg/kg (550mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Polish Journal of Pharmacology and Pharmacy. Vol. 32, Pg. 823, 1980.
mouse LD50 intravenous 18mg/kg (18mg/kg)   Drugs of the Future. Vol. 5, Pg. 610, 1980.
mouse LD50 oral 4500mg/kg (4500mg/kg)   Drugs of the Future. Vol. 5, Pg. 610, 1980.
rabbit LD50 intravenous 2500ug/kg (2.5mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 32, Pg. 833, 1980.
rat LD50 intraperitoneal 142mg/kg (142mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Polish Journal of Pharmacology and Pharmacy. Vol. 32, Pg. 823, 1980.
rat LD50 intravenous 15800ug/kg (15.8mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA
Polish Journal of Pharmacology and Pharmacy. Vol. 32, Pg. 823, 1980.
rat LD50 oral 1500mg/kg (1500mg/kg)   Drugs of the Future. Vol. 5, Pg. 610, 1980.