Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Sunitinib [INN:BAN]
RN: 557795-19-4
UNII: V99T50803M
InChIKey: WINHZLLDWRZWRT-ATVHPVEESA-N

Note

  • Inhibits VEGF-R2 and PDGF-Rbeta tyrosine kinase; has antineoplastic activity.

    NCI: sunitinib listen (soo-NIH-tih-nib) A drug used to treat certain types of pancreatic cancer. It is also used to treat gastrointestinal stromal tumors (GIST) in some patients and to treat advanced kidney cancer. It is being studied in the treatment of other types of cancer. Sunitinib stops cancer cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of angiogenesis inhibitor. Also called SU011248, SU11248, sunitinib malate, and Sutent.

Molecular Formula

  • C22-H27-F-N4-O2

Molecular Weight

  • 398.4793
 

Classification Codes

  • Angiogenesis Inhibitors
  • Angiogenesis Modulating Agents
  • Antineoplastic Agents
  • Growth Inhibitors
  • Growth Substances
  • Protein Kinase Inhibitors

Names and Synonyms

Name of Substance

  • Sunitinib [INN:BAN]

Synonyms

  • HSDB 7932
  • Su-011248
  • SU-11248
  • Sunitinib
  • Sutent
  • UNII-V99T50803M

Systematic Names

  • 1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-
  • SU 11248

Registry Numbers

CAS Registry Number

  • 557795-19-4

FDA UNII

  • V99T50803M

Other Registry Number

  • 326914-13-0

System Generated Number

  • 0557795194

Structure Descriptors

InChI

1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-

InChIKey

WINHZLLDWRZWRT-ATVHPVEESA-N

Smiles

c1cc(cc2c1NC(=O)C\2=C/c1[nH]c(c(c1C)C(=O)NCCN(CC)CC)C)F