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Substance Name: Metoclopramide dihydrochloride monohydrate
RN: 5581-45-3
UNII: W1KXE205VU
InChIKey: IRQVJPHZDYMXNW-UHFFFAOYSA-N

Molecular Formula

  • C14-H22-Cl-N3-O2.2Cl-H.H2-O

Molecular Weight

  • 390.7364
 
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Names and Synonyms

Results Name

  • Metoclopramide dihydrochloride monohydrate

Name of Substance

  • Metoclopramide dihydrochloride monohydrate

Synonyms

  • 2-Methoxy-4-amino-5-chloro-N-(beta-(diethylamino)ethyl)benzamide dihydrochloride monohydrate
  • 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide dihydrochloride monohydrate
  • Metadrate
  • Metoclopramide dihydrochloride monohydrate
  • Metoclopramide HCl hydrate
  • UNII-W1KXE205VU

Systematic Name

  • o-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-, dihydrochloride, monohydrate

Registry Numbers

CAS Registry Number

  • 5581-45-3

FDA UNII

  • W1KXE205VU

System Generated Number

  • 0005581453

Molecular Formulas

Molecular Formula

  • C14-H22-Cl-N3-O2.2Cl-H.H2-O

Molecular Formula Fragments

  • C14-H22-Cl-N3-O2
  • Cl-H
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

1S/C14H22ClN3O2.2ClH.H2O/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;;;/h8-9H,4-7,16H2,1-3H3,(H,17,19);2*1H;1H2

InChIKey

IRQVJPHZDYMXNW-UHFFFAOYSA-N

Smiles

O.Cl.Cl.CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 138mg/kg (138mg/kg)   Anesthesie, Analgesie, Reanimation. Vol. 23, Pg. 663, 1966.
mouse LD50 intravenous 37500ug/kg (37.5mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
mouse LD50 oral 335mg/kg (335mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
mouse LD50 subcutaneous 233mg/kg (233mg/kg)   Anesthesie, Analgesie, Reanimation. Vol. 23, Pg. 663, 1966.
rabbit LD50 intravenous 23mg/kg (23mg/kg)   Anesthesie, Analgesie, Reanimation. Vol. 23, Pg. 663, 1966.
rat LD50 intraperitoneal 130mg/kg (130mg/kg)   Anesthesie, Analgesie, Reanimation. Vol. 23, Pg. 663, 1966.
rat LD50 intravenous 42100ug/kg (42.1mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
rat LD50 oral 647mg/kg (647mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
rat LD50 subcutaneous 633mg/kg (633mg/kg)   Anesthesie, Analgesie, Reanimation. Vol. 23, Pg. 663, 1966.