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Substance Name: Atropine sulfate mixture with diphenoxylate hydrochloride
RN: 55840-97-6
InChIKey: HKIGPMUNBXIAHY-UHFFFAOYSA-N

Note

  • Contains diphenoxylate & atropine sulfate.

Classification Codes

  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Human Data

Molecular Formula

  • C30-H32-N2-O2.C17-H23-N-O3.Cl-H.1/2H2-O4-S

Molecular Weight

  • 876.5062
 
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Names and Synonyms

Results Name

  • Atropine sulfate mixture with diphenoxylate hydrochloride

Name of Substance

  • Atropine sulfate-diphenoxylate hydrochloride drug combination

Synonyms

  • Atropine mixture with diphenoxylate
  • Atropine sulfate - diphenoxylate hydrochloride
  • Atropine sulfate and diphenoxylate hydrochloride
  • Colonaid
  • Di-Atro
  • Diphenoxylate hydrochloride and atropine sulfate
  • Diphenoxylate hydrochloride w/ atropine sulfate
  • Diphenoxylate-atropine
  • Lo-Trol
  • Logen
  • Lomanate
  • Lomotil
  • Lonox
  • Low-Quel
  • Reasec

Systematic Name

  • 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride, mixt. with endo-(+-)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl alpha-(hydroxymethyl)benzeneacetate sulfate (2:1) (salt)

Superlist Names

  • Diphenoxylate preparations 2.5 mg/25 ug AtSO4
  • Lomotil

Registry Numbers

CAS Registry Number

  • 55840-97-6

System Generated Number

  • 0055840976

Molecular Formulas

Molecular Formula

  • C30-H32-N2-O2.C17-H23-N-O3.Cl-H.1/2H2-O4-S

Molecular Formula Fragments

  • C17-H23-N-O3
  • C30-H32-N2-O2
  • Cl-H
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

InChI=1S/C30H32N2O2.C17H23NO3.ClH.H2O4S/c1-2-34-28(33)29(25-12-6-3-7-13-25)18-21-32(22-19-29)23-20-30(24-31,26-14-8-4-9-15-26)27-16-10-5-11-17-27;1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;;1-5(2,3)4/h3-17H,2,18-23H2,1H3;2-6,13-16,19H,7-11H2,1H3;1H;(H2,1,2,3,4)

InChIKey

HKIGPMUNBXIAHY-UHFFFAOYSA-N

Smiles

Cl.CCOC(=O)C1(CCN(CCC(C#N)(c2ccccc2)c3ccccc3)CC1)c4ccccc4.CN5C6CCC5CC(C6)OC(=O)C(CO)c7ccccc7.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child LDLo oral 1212ug/kg (1.212mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Clinical Toxicology. Vol. 2, Pg. 377, 1969.
child LDLo oral 1515ug/kg (1.515mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: OTHER CHANGES
Lancet. Vol. 1, Pg. 150, 1969.
child TDLo oral 2300ug/kg (2.3mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives of Disease in Childhood. Vol. 54, Pg. 222, 1979.
child TDLo oral 5250ug/kg (5.25mg/kg) BEHAVIORAL: EXCITEMENT

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BEHAVIORAL: ATAXIA
Pediatrics. Vol. 87, Pg. 694, 1991.