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Substance Name: Methoxyphenamine hydrochloride [USP:JAN]
RN: 5588-10-3
UNII: 52V8BVV7FX
InChIKey: FGSJNNQVSUVTPW-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C11-H17-N-O.Cl-H

Molecular Weight

  • 215.7222
 
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Names and Synonyms

Name of Substance

  • Methoxyphenamine hydrochloride
  • Methoxyphenamine hydrochloride [USP:JAN]

Synonyms

  • alpha-(2-Methoxyphenyl)-beta-methylaminopropane hydrochloride
  • Benzeneethanamine, 2-methoxy-N,2-dimethyl-, hydrochloride
  • Benzeneethanamine, 2-methoxy-N,alpha-dimethyl-, hydrochloride
  • beta-(o-Methoxyphenyl)isopropylmethylamine hydrochloride
  • beta-(o-Methoxyphenyl)isoptropylmethylamine hydrochloride
  • EINECS 226-993-2
  • Methoxiphenadrin hydrochloride
  • Methoxyphenamine HCl
  • Methoxyphenamine hydrochloride
  • Methoxyphenaminium chloride
  • N,alpha-Dimethyl-o-methoxy-phenethylamine hydrochloride
  • NSC 65644
  • o-Methoxy-N, alpha-dimethylphenethylamine hydrochloride
  • o-Methoxy-N,alpha-dimethylphenethylamine hydrochloride
  • o-Methoxymethamphetamine hydrochloride
  • Orthoxine hydrochloride
  • Ortodrinex hydrochloride
  • Phenethylamine, N,alpha-dimethyl-o-methoxy-, hydrochloride
  • Phenethylamine, o-methoxy-N, alpha-dimethyl-, hydrochloride
  • Proasma hydrochloride
  • UNII-52V8BVV7FX

Systematic Names

  • Benzeneethanamine, 2-methoxy-N,alpha-dimethyl-, hydrochloride
  • Methoxyphenamine hydrochloride
  • Phenethylamine, o-methoxy-N, alpha-dimethyl-, hydrochloride
  • Phenethylamine, o-methoxy-N,alpha-dimethyl-, hydrochloride (8CI)

Mixture Name

  • Orthoxicol

Registry Numbers

CAS Registry Number

  • 5588-10-3

FDA UNII

  • 52V8BVV7FX

Related Registry Number

  • 93-30-1 (Parent)

System Generated Number

  • 0005588103

Molecular Formulas

Molecular Formula

  • C11-H17-N-O.Cl-H

Molecular Formula Fragments

  • C11-H17-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C11H17NO.ClH/c1-9(12-2)8-10-6-4-5-7-11(10)13-3;/h4-7,9,12H,8H2,1-3H3;1H

InChIKey

FGSJNNQVSUVTPW-UHFFFAOYSA-N

Smiles

Cl.CNC(C)Cc1ccccc1OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 subcutaneous 241mg/kg (241mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 688, 1958.
mouse LD50 intraperitoneal 90mg/kg (90mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 348, 1972.
mouse LD50 oral 605mg/kg (605mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 55, Pg. 653, 1959.
mouse LD50 subcutaneous 380mg/kg (380mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 55, Pg. 653, 1959.
rabbit LD50 intravenous 30mg/kg (30mg/kg)   Drugs in Japan Vol. 6, Pg. 837, 1982.
rabbit LD50 oral 652mg/kg (652mg/kg)   Drugs in Japan Vol. 6, Pg. 837, 1982.
rabbit LD50 subcutaneous 269mg/kg (269mg/kg)   Drugs in Japan Vol. 6, Pg. 837, 1982.
rat LD50 intravenous 50mg/kg (50mg/kg)   Drugs in Japan Vol. 6, Pg. 837, 1982.
rat LD50 oral 630mg/kg (630mg/kg)   Drugs in Japan Vol. 6, Pg. 837, 1982.
rat LD50 subcutaneous 573mg/kg (573mg/kg)   Drugs in Japan Vol. 6, Pg. 837, 1982.