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Substance Name: Mesoridazine [USAN:INN:BAN]
RN: 5588-33-0
UNII: 5XE4NWM740
InChIKey: SLVMESMUVMCQIY-UHFFFAOYSA-N

Note

  • A phenothiazine antipsychotic with effects similar to CHLORPROMAZINE.

Molecular Formula

  • C21-H26-N2-O-S2

Molecular Weight

  • 386.5814
 

Classification Codes

  • Antipsychotic
  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Dopamine Agents
  • Dopamine Antagonists
  • Human Data
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Tranquilizing Agents

Names and Synonyms

Name of Substance

  • Mesoridazine
  • Mesoridazine [USAN:INN:BAN]

MeSH Heading

  • Mesoridazine

Synonyms

  • 10-(2(1-Methyl-2-piperidyl)ethyl)-2-(methylsulfinyl)-phenothiazine
  • 10-(2-(1-Methyl-2-piperidinyl)ethyl)-2-(methylsulfinyl)-10H-phenothiazine
  • 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylsulfinyl phenothiazine
  • 10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylsulfinyl)-
  • Calodal
  • HSDB 3357
  • Lidanar
  • Lidanil
  • Mesoridazina
  • Mesoridazina [INN-Spanish]
  • Mesoridazine
  • Mesoridazinum
  • Mesoridazinum [INN-Latin]
  • NC-123
  • NSC 186066
  • Serentil
  • T-2-SO
  • THD-2-SO
  • Thioridazine thiomethyl sulfoxide
  • Thioridazine-2-sulfoxide
  • TPS 23
  • TPS-23
  • TPS23
  • UNII-5XE4NWM740

Systematic Name

  • 10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylsulfinyl)-

Registry Numbers

CAS Registry Number

  • 5588-33-0

FDA UNII

  • 5XE4NWM740

System Generated Number

  • 0005588330

Structure Descriptors

InChI

1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3

InChIKey

SLVMESMUVMCQIY-UHFFFAOYSA-N

Smiles

CN1CCCCC1CCN2c3ccccc3Sc4c2cc(cc4)S(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human LDLo oral 42mg/kg (42mg/kg) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BLOOD: HEMORRHAGE
Archives of General Psychiatry. Vol. 34, Pg. 955, 1977.
man TDLo oral 86mg/kg (86mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Journal of Clinical Pyschopharmacology. Vol. 2, Pg. 222, 1982.
mouse LD50 intravenous 26mg/kg (26mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 29, 1972.
mouse LD50 oral 560mg/kg (560mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 29, 1972.
rabbit LD50 intramuscular 405mg/kg (405mg/kg)   Toxicology and Applied Pharmacology. Vol. 19, Pg. 363, 1971.
rabbit LDLo oral 800mg/kg (800mg/kg)   Toxicology and Applied Pharmacology. Vol. 19, Pg. 363, 1971.
rat LD50 intramuscular 509mg/kg (509mg/kg)   Toxicology and Applied Pharmacology. Vol. 19, Pg. 363, 1971.
rat LD50 oral 644mg/kg (644mg/kg)   Toxicology and Applied Pharmacology. Vol. 19, Pg. 363, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 5.630 (none)   EST
Water Solubility 0.045 mg/L 25 EST
Vapor Pressure 7.90E-11 mm Hg 25 EST
Henry's Law Constant 9.44E-16 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.92E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.