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Substance Name: Midecamycin acetate [JAN]
RN: 55881-07-7
UNII: 3T48CPS7U2
InChIKey: GQNZGCARKRHPOH-RQIKCTSVSA-N

Note

  • A macrolide antibiotic that has a wide antimicrobial spectrum and is particularly effective in respiratory and genital infections.

Molecular Formula

  • C45-H71-N-O17

Molecular Weight

  • 898.046
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Midecamycin acetate [JAN]
  • Miocamycin
  • Miokamycin

MeSH Heading

  • Miocamycin

Synonyms

  • 3'',9-Diacetylmydecamycin
  • 9,3''-Diacetylmidecamycin
  • Acecamycin
  • EINECS 259-879-6
  • Midecamycin acetate
  • Miocamycin
  • Miokamycin
  • MOM
  • Ponsinomycin
  • UNII-3T48CPS7U2

Systematic Names

  • Leucomycin V, 3(sup B),9-diacetate 3,4(sup B)-dipropanoate
  • Leucomycin V, 3B,9-diacetate 3,4B-dipropanoate

Registry Numbers

CAS Registry Number

  • 55881-07-7

FDA UNII

  • 3T48CPS7U2

System Generated Number

  • 0055881077

Structure Descriptors

InChI

1S/C45H71NO17/c1-13-34(50)59-33-23-36(52)55-26(4)18-16-15-17-19-32(58-29(7)48)25(3)22-31(20-21-47)41(42(33)54-12)62-44-39(53)38(46(10)11)40(27(5)57-44)61-37-24-45(9,63-30(8)49)43(28(6)56-37)60-35(51)14-2/h15-17,19,21,25-28,31-33,37-44,53H,13-14,18,20,22-24H2,1-12H3/b16-15+,19-17+/t25-,26-,27-,28+,31+,32+,33-,37+,38-,39-,40-,41+,42+,43+,44+,45-/m1/s1

InChIKey

GQNZGCARKRHPOH-RQIKCTSVSA-N

Smiles

O([C@@H]1[C@H]([C@@H](CC(O[C@@H](CC=CC=C[C@@H]([C@@H](C[C@@H]1CC=O)C)OC(C)=O)C)=O)OC(CC)=O)OC)[C@H]1[C@@H]([C@H]([C@H](O[C@H]2C[C@]([C@@H](OC(CC)=O)[C@@H](O2)C)(OC(C)=O)C)[C@H](O1)C)N(C)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intraperitoneal > 5gm/kg (5000mg/kg)   Japanese Journal of Antibiotics. Vol. 37, Pg. 1313, 1984.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Japanese Journal of Antibiotics. Vol. 37, Pg. 1565, 1984.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Japanese Journal of Antibiotics. Vol. 37, Pg. 1565, 1984.
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 1331, 1995.