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Substance Name: Iosefamic acid [USAN:INN]
RN: 5591-33-3
UNII: DRT553A48W
InChIKey: RXUVYYAWLAIABB-UHFFFAOYSA-N

Classification Code

  • Diagnostic Aid (Radiopaque Medium)

Molecular Formula

  • C28-H28-I6-N4-O8

Molecular Weight

  • 1309.95
 
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Names and Synonyms

Name of Substance

  • Iosefamic acid [USAN:INN]

Synonyms

  • 5,5'-(Octamethylenebis(carbonylimino))bis(N-methyl-2,4,6-triiodoisophthalamic acid)
  • 5,5'-(Sebacoyldiimino)bis(2,4,6-triiodo-N-methylisophthalamic acid)
  • Acide iosefamique
  • Acide iosefamique [INN-French]
  • Acido iosefamico
  • Acido iosefamico [INN-Spanish]
  • Acidum iosefamicum
  • Acidum iosefamicum [INN-Latin]
  • Acidum josefamicum
  • Benzoic acid, 3,3'-((1,10-dioxo-1,10-decanediyl)diimino)bis(2,4,6-triiodo-5-((methylamino)carbonyl)-
  • BRN 2800546
  • Iosefamic acid
  • MP 271
  • MP-271
  • UNII-DRT553A48W

Systematic Names

  • Benzoic acid, 3,3'-((1,10-dioxo-1,10-decanediyl)diimino)bis(2,4,6-triiodo-5-((methylamino)carbonyl)-
  • Isophthalamic acid, 5,5'-(octamethylenebis(carbonylimino))bis(N-methyl-2,4,6-triiodo-

Registry Numbers

CAS Registry Number

  • 5591-33-3

FDA UNII

  • DRT553A48W

System Generated Number

  • 0005591333

Structure Descriptors

InChI

1S/C28H28I6N4O8/c1-35-25(41)13-17(29)15(27(43)44)21(33)23(19(13)31)37-11(39)9-7-5-3-4-6-8-10-12(40)38-24-20(32)14(26(42)36-2)18(30)16(22(24)34)28(45)46/h3-10H2,1-2H3,(H,35,41)(H,36,42)(H,37,39)(H,38,40)(H,43,44)(H,45,46)

InChIKey

RXUVYYAWLAIABB-UHFFFAOYSA-N

Smiles

c1(c(c(c(I)c(c1I)C(O)=O)C(NC)=O)I)NC(CCCCCCCCC(Nc1c(c(c(I)c(c1I)C(O)=O)C(NC)=O)I)=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 10gm/kg (10000mg/kg)   Journal of Medicinal Chemistry. Vol. 9, Pg. 964, 1966.
mouse LD50 intracrebral 1120mg/kg (1120mg/kg)   Journal of Medicinal Chemistry. Vol. 9, Pg. 964, 1966.
mouse LD50 intravenous 1576mg/kg (1576mg/kg)   Investigative Radiology. Vol. 15, Pg. S248, 1980.
rat LD50 intravenous 6600mg/kg (6600mg/kg)   Journal of Medicinal Chemistry. Vol. 9, Pg. 964, 1966.