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Substance Name: Betamethasone dipropionate [USAN:USP:JAN]
RN: 5593-20-4
UNII: 826Y60901U
InChIKey: CIWBQSYVNNPZIQ-XYWKZLDCSA-N

Classification Codes

  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Hormone
  • Reproductive Effect

Molecular Formula

  • C28-H37-F-O7

Molecular Weight

  • 504.5913
 
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Names and Synonyms

Name of Substance

  • Betamethasone dipropionate [USAN:USP:JAN]
  • Betamethasone-17,21-dipropionate

Synonyms

  • 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate
  • Alphatrex
  • beta-Methasone 17,21-dipropionate
  • Betamethasone 17,21-dipropionate
  • Betamethasone dipropionate
  • BRN 3638108
  • Diproderm
  • Diprolene
  • Diprolene AF
  • Diprosis
  • Diprosone
  • EINECS 227-005-2
  • Maxivate
  • NSC 758415
  • Psorion
  • Rinderon DP
  • S 3440
  • S-3440
  • Sch 11460
  • Sernivo
  • UNII-826Y60901U

Systematic Names

  • 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate)
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-beta-methyl-, 17,21-dipropionate
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11beta,16beta)

Mixture Names

  • Alphatrex
  • Betasone (Veterinary)
  • Lotrisone

Registry Numbers

CAS Registry Number

  • 5593-20-4

FDA UNII

  • 826Y60901U

System Generated Number

  • 0005593204

Structure Descriptors

InChI

InChI=1S/C28H37FO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

InChIKey

CIWBQSYVNNPZIQ-XYWKZLDCSA-N

Smiles

CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 103mg/kg (103mg/kg)   Drugs in Japan Vol. 6, Pg. 753, 1982.
mouse LD50 oral > 5gm/kg (5000mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
mouse LD50 subcutaneous 78100ug/kg (78.1mg/kg)   Drugs in Japan Vol. 6, Pg. 753, 1982.
rat LD50 intraperitoneal > 4gm/kg (4000mg/kg)   Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
rat LD50 oral > 4gm/kg (4000mg/kg)   Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
rat LD50 subcutaneous > 4gm/kg (4000mg/kg)   Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 232 dec deg C   EXP
log P (octanol-water) 4.07 (none)   EXP
Water Solubility 0.724 mg/L 25 EST
Vapor Pressure 9.01E-14 mm Hg 25 EST
Henry's Law Constant 1.47E-15 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.88E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.