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Substance Name: beta-Aminoethylisothiuronium Bromide
RN: 56-10-0
UNII: 03K18418PY
InChIKey: XDVMCVGTDUKDHL-UHFFFAOYSA-N

Note

  • A radiation-protective agent that can inhibit DNA damage by binding to the DNA. It also increases the susceptibility of blood cells to complement-mediated lysis.

Molecular Formula

  • C3-H9-N3-S.2Br-H

Molecular Weight

  • 281.0149
 

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
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Names and Synonyms

Results Name

  • beta-Aminoethylisothiuronium Bromide

Name of Substance

  • beta-Aminoethyl isothiourea

MeSH Heading

  • beta-Aminoethyl isothiourea

Synonyms

  • 2-(2-Aminoethyl)-2-thiopseudourea dihydrobromide
  • 2-(2-Aminoethyl)-2-thiopseudourea hydrobromide
  • 2-(beta-Aminoethyl)isothiouronium bromide hydrobromide
  • 2-Aminoethylisothiouronium dibromide
  • 2-Aminoethylisothiuronium bromide hydrobromide
  • 2-Aminoethylisothiuronium dihydrobromide
  • 2-Aminoethylthiopseudourea dihydrobromide
  • 2beta-Aminoethylisothiourea-bromide-hydrogen bromide
  • A 15591
  • A. E. T.
  • AET
  • AI3-23427
  • Aminoethylisothiuronium bromide hydrobromide
  • Antirad
  • Antiradon
  • beta-Aminoaethyl-isothiuronium dihydrobromid
  • beta-Aminoaethyl-isothiuronium dihydrobromid [German]
  • beta-Aminoethylisothiouronium bromide hydrobromide
  • Carbamimidothioic acid, 2-aminoethyl ester, dihydrobromide
  • EINECS 200-257-0
  • Isothiuronium bromide, aminoethyl-, hydrobromide
  • Ixecur
  • NSC 22877
  • Pseudourea, (2-aminoethyl)-2-thio-, dihydrobromide
  • S-(2-Aminoaethyl)isothiuronium dibromid
  • S-(2-Aminoaethyl)isothiuronium dibromid [German]
  • S-(2-Aminoethyl)isothiuronium dibromide
  • S-(2-Aminoethyl)pseudothiourea dihydrobromide
  • S-2-Aminoethylisothiouronium bromide hydrobromide
  • S-Aminoethylisothiuronium bromide hydrobromide
  • S-beta-Aminoethylisothiuronium bromohydrate
  • Surrectan
  • UNII-03K18418PY
  • USAF XR-31

Systematic Names

  • Carbamimidothioic acid, 2-aminoethyl ester, dihydrobromide
  • Carbamimidothioic acid, 2-aminoethyl ester, hydrobromide (1:2)
  • Pseudourea, (2-aminoethyl)-2-thio-, dihydrobromide
  • S-2-Aminoethylthiouronium bromide hydrobromide

Registry Numbers

CAS Registry Number

  • 56-10-0

FDA UNII

  • 03K18418PY

Other Registry Number

  • 927-71-9

Related Registry Numbers

  • 151-16-6 (parent cpd)
  • 18144-22-4 (sulfate (1:1))
  • 2141-04-0 (mono-hydrobromide)
  • 63680-10-4 (diacetate)
  • 63680-11-5 (diperchlorate)
  • 63680-12-6 (di-hydriodide)
  • 63680-13-7 (phosphate (1:1))
  • 871-25-0 (di-hydrochloride)

System Generated Number

  • 0000056100

Molecular Formulas

Molecular Formula

  • C3-H9-N3-S.2Br-H

Molecular Formula Fragments

  • Br-H
  • C3-H9-N3-S
  • COMPONENT

Structure Descriptors

InChI

1S/C3H9N3S.2BrH/c4-1-2-7-3(5)6;;/h1-2,4H2,(H3,5,6);2*1H

InChIKey

XDVMCVGTDUKDHL-UHFFFAOYSA-N

Smiles

C(CSC(=N)N)N.Br.Br

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intraperitoneal 113mg/kg (113mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 142, Pg. 510, 1963.
dog LD50 oral 177mg/kg (177mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 142, Pg. 510, 1963.
guinea pig LD50 intraperitoneal 356mg/kg (356mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 218, 1960.
mouse LD50 intraperitoneal 400mg/kg (400mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 intravenous 85400ug/kg (85.4mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 218, 1960.
mouse LD50 oral 815mg/kg (815mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 218, 1960.
mouse LD50 subcutaneous 242mg/kg (242mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 576, 1957.
rabbit LD50 intraperitoneal 236mg/kg (236mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 142, Pg. 510, 1963.
rat LD50 intraperitoneal 288mg/kg (288mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 142, Pg. 198, 1963.
rat LD50 intravenous 85mg/kg (85mg/kg)   Casopis Lekaru Ceskych. Journal of Czech Physicians. Vol. 105, Pg. 1165, 1966.