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Substance Name: Gamma-aminobutyric acid [JAN]
RN: 56-12-2
UNII: 2ACZ6IPC6I
InChIKey: BTCSSZJGUNDROE-UHFFFAOYSA-N
Note
- The most common inhibitory neurotransmitter in the central nervous system.
Molecular Formula
- C4-H9-N-O2
Molecular Weight
- 103.1201
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Drug / Therapeutic Agent
- GABA Agents
- Neurotransmitter Agents
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Names and Synonyms
Name of Substance
- Butanoic acid, 4-amino-
- GABA
- Gamma-aminobutyric acid [JAN]
MeSH Heading
- gamma-Aminobutyric acid
Synonyms
- 4-Aminobutanoic acid
- 4-Aminobutyric acid
- Acide amino-4- butyrique
- Acide amino-4- butyrique [French]
- AI3-26812
- Aminalon
- Aminalone
- CCRIS 3721
- DF 468
- EINECS 200-258-6
- EPA Pesticide Chemical Code 030802
- GABA
- Gaballon
- Gamarex
- Gamastan
- gamma-Amino-n-butyric acid
- gamma-Aminobutanoic acid
- gamma-Aminobuttersaeure
- gamma-Aminobuttersaeure [German]
- gamma-Aminobutyric acid
- Gammagee
- Gammalon
- Gammalone
- Gammar
- Gammasol
- Gamulin
- Immu-G
- Mielogen
- Mielomade
- NSC 27418
- Piperidic acid
- Piperidinic acid
- Reanal
- UNII-2ACZ6IPC6I
Systematic Names
- 4-Aminobutyric acid
- Butanoic acid, 4-amino-
- Butyric acid, 4-amino-
- gamma-Amino-n-butyric acid
- gamma-Aminobutyric acid
Registry Numbers
CAS Registry Number
- 56-12-2
FDA UNII
- 2ACZ6IPC6I
Other Registry Number
- 3131-86-0
Related Registry Numbers
- 5959-35-3 (hydrochloride)
- 6610-05-5 (mono-hydrochloride salt)
- 70582-09-1 (calcium salt (2:1))
System Generated Number
- 0000056122
Structure Descriptors
InChI
InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)InChIKey
BTCSSZJGUNDROE-UHFFFAOYSA-NSmiles
NCCCC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | intravenous | 5gm/kg (5000mg/kg) | Russian Pharmacology and Toxicology Vol. 47, Pg. 205, 1984. | |
mouse | LD50 | intraperitoneal | 4950mg/kg (4950mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: GENERAL ANESTHETIC | Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965. |
mouse | LD50 | intravenous | 2748mg/kg (2748mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 145, Pg. 233, 1963. | |
mouse | LD50 | oral | 12680mg/kg (12680mg/kg) | Yakugaku Zasshi. Journal of Pharmacy. Vol. 85, Pg. 463, 1965. | |
mouse | LD50 | subcutaneous | 9210mg/kg (9210mg/kg) | Yakugaku Zasshi. Journal of Pharmacy. Vol. 85, Pg. 463, 1965. | |
mouse | LD50 | unreported | 7230mg/kg (7230mg/kg) | Bitamin. Vol. 25, Pg. 297, 1962. | |
rabbit | LDLo | intravenous | 2400mg/kg (2400mg/kg) | Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965. | |
rat | LD50 | intraperitoneal | 5400mg/kg (5400mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: GENERAL ANESTHETIC | Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965. |
rat | LD50 | intravenous | > 5gm/kg (5000mg/kg) | United States Patent Document. Vol. #3380887, | |
rat | LDLo | intracrebral | 18mg/kg (18mg/kg) | Biochemical Pharmacology. Vol. 14, Pg. 1901, 1965. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 203 dec | deg C | EXP | |
pKa Dissociation Constant | 4.0459 | (none) | 15 | EXP |
log P (octanol-water) | -3.17E+00 | (none) | EXP | |
Water Solubility | 1.30E+06 | mg/L | 25 | EXP |
Vapor Pressure | 1.98E-08 | mm Hg | 25 | EST |
Henry's Law Constant | 9.93E-11 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 3.45E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.