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Substance Name: Parathion [BSI:ISO]
RN: 56-38-2
UNII: 61G466064D
InChIKey: LCCNCVORNKJIRZ-UHFFFAOYSA-N

Note

  • A highly toxic cholinesterase inhibitor that is used as an acaricide and as an insecticide.

Molecular Formula

  • C10-H14-N-O5-P-S

Molecular Weight

  • 291.263
 

Classification Codes

Classification Codes

  • Acaricide
  • Agricultural Chemical
  • Avicide
  • Cholinergic Agents
  • Cholinesterase Inhibitors
  • Enzyme Inhibitors
  • Human Data
  • Insecticide
  • Insecticides
  • Mutation Data
  • Neurotransmitter Agents
  • Pesticides
  • Reproductive Effect
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 145
  • 2011 CERCLA Priority List, Rank: 149
  • Overall Carcinogenic Evaluation: Group 3
  • Reportable Quantity (RQ) = 10 lb
  • Threshold Planning Quantity (TPQ) = 100 lb
  • TWA 0.05 mg/m3 inhalable fraction vapor and aerosol; skin; Not classifiable as a human carcinogen, BEI
  • TWA 0.1 mg/m3; skin

Names and Synonyms

Name of Substance

  • Parathion [BSI:ISO]

MeSH Heading

  • Parathion

Synonyms

  • 4-06-00-01337 (Beilstein Handbook Reference)
  • AAT [Pesticide]
  • AATP
  • AC 3422
  • AI3-15108
  • Alkron
  • Alleron
  • American cyanamid 3422
  • Aphamite
  • Aralo
  • BAY E-605
  • Bayer E-605
  • Bladan F
  • BRN 2059093
  • Caswell No. 637
  • CCRIS 493
  • Corothion
  • Corthione
  • Danthion
  • Diethyl 4-nitrophenyl phosphorothionate
  • Diethyl p-nitrophenyl phosphorothionate
  • Diethyl p-nitrophenyl thionophosphate
  • Diethyl p-nitrophenyl thiophosphate
  • Diethyl para-nitrophenol thiophosphate
  • Diethyl parathion
  • Dietil tiofosfato de p-nitrofenila
  • Dietil tiofosfato de p-nitrofenila [Portuguese]
  • Drexel parathion 8E
  • E 605
  • E 605 F
  • E 605 forte
  • E-605
  • Ecatox 20
  • EINECS 200-271-7
  • Ekatin WF & WF ULV
  • Ekatox
  • Ekatox 20
  • ENT 15,108
  • EPA Pesticide Chemical Code 057501
  • EPA Shaughnessy Code: 057501
  • Ethyl parathion
  • Ethyl parathion 50 EC
  • Ethylparathion
  • Etilon
  • Etylparation
  • Etylparation [Czech]
  • Folidol
  • Folidol E
  • Folidol E & E 605
  • Folidol E605
  • Folidol oil
  • Fosferno
  • Fosfive
  • Fosova
  • Fostox
  • Gearphos
  • Genithion
  • HSDB 197
  • Kolphos
  • Kypthion
  • Lethalaire G-54
  • Lirothion
  • Murfos
  • NCI-C00226
  • Niran
  • Niran E-4
  • Nitrostigmin
  • Nitrostigmin [German]
  • Nitrostigmine
  • NIUIF-100
  • Nourithion
  • NSC 8933
  • O,O-Diaethyl-O-(4-nitro-phenyl)-monothiophosphat
  • O,O-Diaethyl-O-(4-nitro-phenyl)-monothiophosphat [German]
  • O,O-Diethyl O-(p-nitrophenyl) phosphorothioate
  • O,O-Diethyl O-(p-nitrophenyl) thionophosphate
  • O,O-Diethyl O-4-nitrophenyl thiophosphate
  • O,O-Diethyl O-p-nitrophenyl thiophosphate
  • O,O-Diethyl O-p-nitrophenylphosphorothioate
  • O,O-Diethyl-O-(4-nitro-fenil)-monothiofosfaat
  • O,O-Diethyl-O-(4-nitro-fenil)-monothiofosfaat [Dutch]
  • O,O-Diethyl-O-(4-nitrophenyl) phosphorothioate
  • O,O-Diethyl-O-(p-nitrophenyl)thionophosphate
  • O,O-Diethyl-O-p-nitrofenylester kyseliny thiofosforecne
  • O,O-Diethyl-O-p-nitrofenylester kyseliny thiofosforecne [Czech]
  • O,O-Dietil-O-(4-nitro-fenil)-monotiofosfato
  • O,O-Dietil-O-(4-nitro-fenil)-monotiofosfato [Italian]
  • O,O-Dietyl-O-p-nitrofenyltiofosfat
  • O,O-Dietyl-O-p-nitrofenyltiofosfat [Czech]
  • Oleofos 20
  • Oleoparaphene
  • Oleoparathion
  • OMS 19
  • Orthophos
  • p-Nitrophenyl diethyl thiophosphate
  • Pacol
  • Panthion
  • Paradust
  • Paramar
  • Paramar 50
  • Paraphos
  • Parathene
  • Parathion
  • Parathion 20 wp
  • Parathion ethyl
  • Parathion-aethyl
  • Parathion-aethyl [German]
  • Parathion-ethyl
  • Parawet
  • Penncap E
  • Pestox plus
  • Pethion
  • Phenol, p-nitro-, O-ester with O,O-diethyl phosphorothioate
  • Phenol, p-nitro-, O-ester with O,O-diethylphosphorothioate
  • Phoskil
  • Phosphemol
  • Phosphenol
  • Phosphorothioic acid, O,O-diethyl O-(4-nitrophenyl) ester
  • Phosphostigmine
  • RB
  • RCRA waste number P089
  • Rhodiasol
  • Rhodiatox
  • Selephos
  • Sixty-three special EC insecticide
  • SNP
  • Soprathion
  • Soprothion
  • Stabilized ethyl parathion
  • Stathion
  • Strathion
  • Sulphos
  • Super Rodiatox
  • T-47
  • Thiofos
  • Thiomex
  • Thiophos
  • Thiophos 3422
  • Thiophosphate de O,O-diethyle et de O-(4-nitrophenyle)
  • Thiophosphate de O,O-diethyle et de O-(4-nitrophenyle) [French]
  • Tiofos
  • TOX 47
  • UN 2783
  • UNII-61G466064D
  • Vapophos
  • Vitrex

Systematic Names

  • Parathion
  • Phosphorothioic acid, O,O-diethyl O-(4-nitrophenyl) ester
  • Phosphorothioic acid, O,O-diethyl O-(p-nitrophenyl) ester

Superlist Names

  • NA1967
  • NA2783
  • Parathion
  • Parathion and compressed gas mixture
  • Parathion and compressed gas mixture [NA1967] [Poison gas]
  • Parathion [NA2783] [Poison]
  • Phosphorothioic acid, O,O-diethyl O-(4-nitrophenyl) ester
  • RCRA waste no. P089

Registry Numbers

CAS Registry Number

  • 56-38-2

FDA UNII

  • 61G466064D

Other Registry Numbers

  • 110616-89-2
  • 11111-91-4
  • 8057-70-3

System Generated Number

  • 0000056382

Structure Descriptors

InChI

1S/C10H14NO5PS/c1-3-14-17(18,15-4-2)16-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3

InChIKey

LCCNCVORNKJIRZ-UHFFFAOYSA-N

Smiles

P(Oc1ccc([N+](=O)[O-])cc1)(OCC)(OCC)=S

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 1330ug/kg (1.33mg/kg)   ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979.
bird - wild LD50 skin 1800ug/kg (1.8mg/kg)   Toxicology and Applied Pharmacology. Vol. 26, Pg. 154, 1973.
cat LD50 intraperitoneal 3mg/kg (3mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 79, 1949.
cat LD50 intravenous 3mg/kg (3mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
JAMA, Journal of the American Medical Association. Vol. 144, Pg. 104, 1950.
cat LD50 oral 930ug/kg (0.93mg/kg)   Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961.
chicken LD50 intraperitoneal 2500ug/kg (2.5mg/kg)   Environmental Quality and Safety. Vol. 3, Pg. 173, 1974.
chicken LD50 oral 10mg/kg (10mg/kg)   Environmental Quality and Safety. Vol. 3, Pg. 173, 1974.
dog LC inhalation > 37130ug/m3/4 (37.13mg/m3)   National Technical Information Service. Vol. AD-A041-973,
dog LD50 intraperitoneal 12mg/kg (12mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR
Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 79, 1949.
dog LD50 intravenous 12mg/kg (12mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
JAMA, Journal of the American Medical Association. Vol. 144, Pg. 104, 1950.
dog LD50 oral 3mg/kg (3mg/kg)   Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 33, 1978.
domestic animals - goat/sheep LDLo intramuscular 20mg/kg (20mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: REGIDITY
U.S. Army, Chemical Corps Medical Laboratories Research Reports. Vol. #269, Pg. 1954,
domestic animals - goat/sheep LDLo oral 100mg/kg (100mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: REGIDITY
U.S. Army, Chemical Corps Medical Laboratories Research Reports. Vol. #269, Pg. 1954,
duck LD50 oral 2100ug/kg (2.1mg/kg)   Down to Earth. Vol. 35, Pg. 25, 1979.
duck LD50 skin 28mg/kg (28mg/kg)   Toxicology and Applied Pharmacology. Vol. 47, Pg. 451, 1979.
frog LD50 parenteral 967mg/kg (967mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 124, Pg. 212, 1960.
guinea pig LCLo inhalation 14mg/m3/2H (14mg/m3)   AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 5, Pg. 44, 1952.
guinea pig LD50 intraperitoneal 12mg/kg (12mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 626, 1955.
guinea pig LD50 oral 8mg/kg (8mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 626, 1955.
guinea pig LD50 skin 45mg/kg (45mg/kg)   Toxicological Information on Cyanamid Insecticides. Vol. 8/1966,
guinea pig LD50 subcutaneous 10mg/kg (10mg/kg)   Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965.
guinea pig LD50 subcutaneous 10mg/kg (10mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965.
horse/donkey LD50 oral 5mg/kg (5mg/kg)   "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
human LD50 oral 3mg/kg (3mg/kg)   "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A311, Pg. 1986,
human LDLo intratracheal 714ug/kg (0.714mg/kg)   Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. Vol. 9, Pg. 1, 1968.
human LDLo oral 171ug/kg (0.171mg/kg)   "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956Vol. -, Pg. 1, 1956.
human LDLo skin 7143ug/kg (7.143mg/kg)   Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. Vol. 9, Pg. 1, 1968.
mammal (species unspecified) LD50 oral 49mg/kg (49mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
National Technical Information Service. Vol. PB288-416,
mammal (species unspecified) LD50 unreported 6mg/kg (6mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 323, 1971.
man LDLo unreported 1471ug/kg (1.471mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo oral 429ug/kg/4D-I (0.429mg/kg)   Toxicology and Applied Pharmacology. Vol. 14, Pg. 603, 1969.
man TDLo oral 214mg/kg (214mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: COMA
Journal of Neurology, Neurosurgery and Psychiatry. Vol. 56, Pg. 1135, 1993.
man TDLo oral 2143mg/kg (2143mg/kg) VASCULAR: SHOCK

CARDIAC: PULSE RATE

BEHAVIORAL: COMA
Neurology. Vol. 31, Pg. 603, 1981.
mouse LCLo inhalation 15mg/m3 (15mg/m3)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 52, 1982.
mouse LD50 intramuscular 7200ug/kg (7.2mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 237, Pg. 211, 1959.
mouse LD50 intraperitoneal 3mg/kg (3mg/kg)   Journal of Agricultural and Food Chemistry. Vol. 11, Pg. 91, 1963.
mouse LD50 intravenous 13mg/kg (13mg/kg)   Toxicology and Applied Pharmacology. Vol. 22, Pg. 684, 1972.
mouse LD50 oral 5mg/kg (5mg/kg)   Agricultural and Biological Chemistry. Vol. 30, Pg. 181, 1966.
mouse LD50 skin 19mg/kg (19mg/kg)   Agricultural and Biological Chemistry. Vol. 26, Pg. 257, 1962.
mouse LD50 subcutaneous 10mg/kg (10mg/kg)   Pharmazie. Vol. 37, Pg. 729, 1982.
mouse LD50 unreported 14500ug/kg (14.5mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(5), Pg. 38, 1963.
pigeon LD50 oral 1330ug/kg (1.33mg/kg)   ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979.
quail LD50 oral 4040ug/kg (4.04mg/kg)   Pesticide Biochemistry and Physiology. Vol. 7, Pg. 28, 1977.
rabbit LCLo inhalation 50mg/m3/2H (50mg/m3)   AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 5, Pg. 44, 1952.
rabbit LD50 oral 10mg/kg (10mg/kg)   Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 33, 1978.
rabbit LD50 skin 15mg/kg (15mg/kg)   Toxicological Information on Cyanamid Insecticides. Vol. 8/1966,
rabbit LD50 subcutaneous 30mg/kg (30mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965.
rat LC50 inhalation 84mg/m3/4H (84mg/m3) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
National Technical Information Service. Vol. AD-A041-973,
rat LD50 intramuscular 6mg/kg (6mg/kg)   Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958.
rat LD50 intraperitoneal 2mg/kg (2mg/kg)   Advances in Pest Control Research. Vol. 4, Pg. 117, 1961.
rat LD50 intratracheal 6200ug/kg (6.2mg/kg)   JAT, Journal of Applied Toxicology. Vol. 19, Pg. 133, 1999.
rat LD50 intravenous 3800ug/kg (3.8mg/kg)   Canadian Journal of Biochemistry and Physiology. Vol. 34, Pg. 197, 1956.
rat LD50 oral 2mg/kg (2mg/kg)   Toxicology and Applied Pharmacology. Vol. 11, Pg. 546, 1967.
rat LD50 skin 6800ug/kg (6.8mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 2, Pg. 88, 1960.
rat LD50 subcutaneous 9mg/kg (9mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965.
women LDLo oral 2350uL/kg (2.35mL/kg) BEHAVIORAL: COMA

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Human & Experimental Toxicology. Vol. 17, Pg. 587, 1998.
women TDLo oral 2mL/kg (2mL/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: COMA
Journal of Toxicology, Clinical Toxicology. Vol. 31, Pg. 497, 1993.
women TDLo oral 5670ug/kg (5.67mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Annals of the New York Academy of Sciences. Vol. 160, Pg. 383, 1969.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 6.1 deg C   EXP
Boiling Point 375 deg C   EXP
log P (octanol-water) 3.83 (none)   EXP
Water Solubility 11 mg/L 20 EXP
Vapor Pressure 6.68E-06 mm Hg 20 EXP
Henry's Law Constant 2.98E-07 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 9.21E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.