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Substance Name: Histamine dihydrochloride [USAN]
RN: 56-92-8
UNII: 3POA0Q644U
InChIKey: PPZMYIBUHIPZOS-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C5-H9-N3.2Cl-H

Molecular Weight

  • 184.0689
 
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Names and Synonyms

Name of Substance

  • Histamine dihydrochloride [USAN]

Synonyms

  • 2-(1H-Imidazol-4-yl)ethanamine dihydrochloride
  • 2-(1H-Imidazol-4-yl)ethylamine dihydrochloride
  • 4-(2-Aminoethyl)imidazole dihydrochloride
  • AI3-24394
  • Bichlorhydrate d'histamine
  • Bichlorhydrate d'histamine [French]
  • Ceplene
  • EINECS 200-298-4
  • Histamine chloride
  • Histamine dichloride
  • Histamine dihydrochloride
  • Histamine HCl
  • Histaminedium dichloride
  • NSC 257873
  • Peremin
  • UNII-3POA0Q644U

Systematic Names

  • 1H-Imidazole-4-ethanamine, dihydrochloride
  • 1H-Imidazole-5-ethanamine, hydrochloride (1:2)
  • 2-Imidazol-4-ylethylamine dihydrochloride
  • Histamine, dihydrochloride

Mixture Name

  • Guna-allergy-prev

Registry Numbers

CAS Registry Number

  • 56-92-8

FDA UNII

  • 3POA0Q644U

System Generated Number

  • 0000056928

Molecular Formulas

Molecular Formula

  • C5-H9-N3.2Cl-H

Molecular Formula Fragments

  • C5-H9-N3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H

InChIKey

PPZMYIBUHIPZOS-UHFFFAOYSA-N

Smiles

c1(CCN)c[nH]cn1.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 4602ug/kg (4.602mg/kg) LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION Journal of Pharmacology and Experimental Therapeutics. Vol. 77, Pg. 54, 1943.
guinea pig LD50 intravenous 290ug/kg (0.29mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2118, 1971.
guinea pig LD50 subcutaneous 1250ug/kg (1.25mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 339, 1966.
guinea pig LDLo parenteral 570ug/kg (0.57mg/kg) VASCULAR: SHOCK Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 211, Pg. 328, 1950.
mouse LD50 intraperitoneal 184mg/kg (184mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977.
mouse LD50 intravenous 370mg/kg (370mg/kg)   Archives of Toxicology, Supplement. Vol. 2, Pg. 371, 1979.
mouse LD50 oral 2534mg/kg (2534mg/kg)   Archives of Toxicology, Supplement. Vol. 2, Pg. 371, 1979.
mouse LDLo subcutaneous 1300mg/kg (1300mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 166, Pg. 437, 1932.
rabbit LDLo intraperitoneal 200mg/kg (200mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE
Journal of Infectious Diseases. Vol. 42, Pg. 473, 1928.
rat LD intracrebral > 28mg/kg (28mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: TREMOR
Polish Journal of Pharmacology and Pharmacy. Vol. 25, Pg. 503, 1973.
rat LD50 intraperitoneal 1550mg/kg (1550mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: REGIDITY

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Actualites Pharmacologiques. Vol. 24, Pg. 51, 1971.