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Substance Name: Chlorhexidine acetate [USP]
RN: 56-95-1
UNII: 5908ZUF22Y
InChIKey: WDRFFJWBUDTUCA-UHFFFAOYSA-N

Note

  • A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

Classification Codes

  • Drug / Therapeutic Agent
  • Skin / Eye Irritant

Molecular Formula

  • C22-H30-Cl2-N10.2C2-H4-O2

Molecular Weight

  • 625.5582
 
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Names and Synonyms

Name of Substance

  • 2,4,11,13-Tetraazatetradecanediimidamide, N,N'-bis(4-chlorophenyl)-3,12-diimino-, diacetate
  • Chlorhexidine acetate [USP]
  • Chlorhexidine diacetate
  • N,N'-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradeca-nediimidamide, diacetate

Synonyms

  • 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) diacetate
  • 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) diacetate
  • 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide)diacetate
  • 1,6-Bis(5-(p-chlorophenyl)biguandino)hexane diacetate
  • 1,6-Bis(p-chlorophenylbiguanido)hexane diacetate
  • 1,6-Di(4'-chlorophenyldiguanidino)hexane diacetate
  • 10,040 Diacetate
  • Bactigras
  • Bis(p-chlorophenyldiguanidohexane) diacetate
  • Caswell No. 481E
  • Chlorhexidine acetate
  • Chlorhexidine acetate (VAN)
  • Chlorhexidine diacetate
  • Chlorohexidine diacetate
  • EINECS 200-302-4
  • EPA Pesticide Chemical Code 045502
  • Hibitane diacetate
  • Nolvasan
  • NSC 526936
  • UNII-5908ZUF22Y

Systematic Names

  • 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, diacetate
  • 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, diacetate (9CI)
  • Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-, diacetate
  • Chlorhexidine di(acetate)

Superlist Names

  • 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide), diacetate
  • Chlorhexidine diacetate

Registry Numbers

CAS Registry Number

  • 56-95-1

FDA UNII

  • 5908ZUF22Y

System Generated Number

  • 0000056951

Molecular Formulas

Molecular Formula

  • C22-H30-Cl2-N10.2C2-H4-O2

Molecular Formula Fragments

  • C2-H4-O2
  • C22-H30-Cl2-N10
  • COMPONENT

Structure Descriptors

InChI

1S/C22H30Cl2N10.2C2H4O2/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*1-2(3)4/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H3,(H,3,4)

InChIKey

WDRFFJWBUDTUCA-UHFFFAOYSA-N

Smiles

CC(=O)O.CC(=O)O.c1cc(ccc1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(cc2)Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 38mg/kg (38mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 9, Pg. 192, 1954.
mouse LD50 intravenous 25mg/kg (25mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 9, Pg. 192, 1954.
mouse LD50 oral 2gm/kg (2000mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 9, Pg. 192, 1954.
mouse LD50 subcutaneous 325mg/kg (325mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 9, Pg. 192, 1954.