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Substance Name: Trimedoxime bromide [INN]
RN: 56-97-3
UNII: ED0GXI9825
InChIKey: JHZHWVQTOXIXIV-UHFFFAOYSA-N

Note

  • Cholinesterase reactivator used as an antidote in alkyl phosphate poisoning.

Molecular Formula

  • C15-H18-N4-O2.2Br

Molecular Weight

  • 446.141
 

Classification Codes

  • Agricultural Chemical
  • Antidotes
  • Cholinergic Agents
  • Cholinesterase Reactivators
  • Enzyme Reactivators
  • Insecticide
  • Neurotransmitter Agents
  • Protective Agents
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Names and Synonyms

Name of Substance

  • Trimedoxime
  • Trimedoxime bromide [INN]

MeSH Heading

  • Trimedoxime

Synonyms

  • 1,1'-Trimethylenebis(4-aldoximinopyridinium) dibromide
  • 1,1'-Trimethylenebis(4-formylpyridine bromide) dioxime
  • 1,1'-Trimethylenebis(4-formylpyridine oxime) dibromide
  • 1,1'-Trimethylenebis(4-formylpyridinium bromide) dioxime
  • 1,1'-Trimethylenebis(4-formylpyridinium) dibromide dioxime
  • 1,3-Bis(4-formylpyridinium)-propane bisoxide dibromide
  • 1,3-Bis(4-hydroxyiminomethyl-1-pyridinium)propane dibromide
  • 1,3-Bis(4-hydroxyiminomethylpyridinium)propane dibromide
  • 1,3-Bis(4-hydroxyiminomethylpyridino)propane dibromide
  • 1,3-Bis(N-pyridine-4-aldoxime)propane dibromide
  • 1,3-Bis(pyridinium-4-aldoxime)propane dibromide
  • 1,3-Propan-bis-(4-hydroxyiminomethyl-pyridinium-(1))-dibromids
  • 1,3-Propan-bis-(4-hydroxyiminomethyl-pyridinium-(1))-dibromids [German]
  • 1,3-Trimethylen-bis-(4-hydroximinoformylpyridinium)-dibromid
  • 1,3-Trimethylen-bis-(4-hydroximinoformylpyridinium)-dibromid [German]
  • 1,3-Trimethylenebis(4-hydroxyiminomethylpyridinium bromide)
  • 4-Hydroxyiminomethyl-(3-(4-hydroxyiminomethyl-1-pyridinio)propyl)pyridinium dibromide
  • Bromure de trimedoxime
  • Bromure de trimedoxime [INN-French]
  • Bromuro de trimedoxima
  • Bromuro de trimedoxima [INN-Spanish]
  • C 434
  • C-434
  • Dipiroksim dibromide
  • Dipiroxim
  • Dipiroxim dibromide
  • Dipyroxim dibromide
  • Dipyroxime
  • EINECS 200-304-5
  • N,N'-Trimethylenebis(4-formylpyridinium bromide) dioxime
  • N,N'-Trimethylenebis(pyridinium-4-aldoxime) dibromide
  • N,N-Trimethylen-bis-(pyridinium-4-aldoxim)-dibromid
  • N,N-Trimethylen-bis-(pyridinium-4-aldoxim)-dibromid [German]
  • NSC 148341
  • TMB-4
  • TMB4
  • Trimedoxime
  • Trimedoxime bromide
  • Trimedoxime N
  • Trimedoximi bromidum
  • Trimedoximi bromidum [INN-Latin]
  • Trimethylenebis(4-hydroxyiminomethylpyridinium) dibromide
  • UNII-ED0GXI9825

Systematic Names

  • 1,1'-Trimethylenebis(4-formylpyridinium bromide)dioxime
  • Pyridinium, 1,1'-(1,3-propanediyl)bis(4-((hydroxyimino)methyl)-, dibromide (9CI)
  • Pyridinium, 1,1'-trimethylenebis(4-formyl-, dibromide, dioxime
  • Trimedoxime bromide

Registry Numbers

CAS Registry Number

  • 56-97-3

FDA UNII

  • ED0GXI9825

System Generated Number

  • 0000056973

Molecular Formulas

Molecular Formula

  • C15-H18-N4-O2.2Br

Molecular Formula Fragments

  • Br
  • C15-H18-N4-O2
  • COMPONENT

Structure Descriptors

InChI

1S/C15H16N4O2.2BrH/c20-16-12-14-2-8-18(9-3-14)6-1-7-19-10-4-15(5-11-19)13-17-21;;/h2-5,8-13H,1,6-7H2;2*1H

InChIKey

JHZHWVQTOXIXIV-UHFFFAOYSA-N

Smiles

[n+]1(ccc(\C=N\O)cc1)CCC[n+]1ccc(\C=N\O)cc1.[BrH-].[BrH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intramuscular 117mg/kg (117mg/kg)   Russian Pharmacology and Toxicology Vol. 38, Pg. 168, 1975.
mouse LD50 intramuscular 100mg/kg (100mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TREMOR
National Technical Information Service. Vol. AD-A133-148,
mouse LD50 intraperitoneal 53500ug/kg (53.5mg/kg)   Russian Pharmacology and Toxicology Vol. 38, Pg. 168, 1975.
mouse LD50 intravenous 45mg/kg (45mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 870, 1964.
mouse LD50 subcutaneous 83mg/kg (83mg/kg)   Russian Pharmacology and Toxicology Vol. 35, Pg. 243, 1972.
rabbit LD50 intravenous 44mg/kg (44mg/kg)   Archives of Environmental Health. Vol. 5, Pg. 21, 1962.
rat LD50 intramuscular 123mg/kg (123mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 31, 1960.
rat LD50 intraperitoneal 192mg/kg (192mg/kg)   Russian Pharmacology and Toxicology Vol. 38, Pg. 168, 1975.
rat LD50 intravenous 89mg/kg (89mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 31, 1960.