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Substance Name: Dextranomer [INN:BAN]
RN: 56087-11-7
UNII: 30KXI0TVD3

Note

  • For treatment of burns; consists of three-dimensional network of dextran polymers cross-linked by epichlorohydrin; dextranomer based implants usedas a bulking agent for endoscopic treatment of pediatric structural incontinence; ingredient of dextranomer-hyaluronic acid copolymer which is used to treat primary vesicoureteral reflux.

Molecular Weight

  • 1028.9
 

Classification Code

  • Drug / Therapeutic Agent
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Links to Resources

Names and Synonyms

Name of Substance

  • Dextranomer
  • Dextranomer [INN:BAN]

Synonyms

  • Debrisan
  • Dextranomer
  • Dextranomere
  • Dextranomere [INN-French]
  • Dextranomero
  • Dextranomero [INN-Spanish]
  • Dextranomerum
  • Dextranomerum [INN-Latin]
  • UNII-30KXI0TVD3

Systematic Name

  • Dextran 2,3-dihydroxypropyl 2-hydroxy-1,3-propanediyl ether

Registry Numbers

CAS Registry Number

  • 56087-11-7

FDA UNII

  • 30KXI0TVD3

System Generated Number

  • 0056087117

Structure Descriptors

Smiles

O1[C@@H]([C@@H](O)[C@@H]([C@H](O)[C@H]1O*)O)CO[C@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)OCC(CO[C@@H]1[C@H](O[C@@H]([C@@H]([C@H]1O)O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O*)O)O)O)CO[C@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)C*)O)CO[C@H]1O[C@H](C*)[C@@H](O)[C@@H](O)[C@H]1O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 10gm/kg (10000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1589, 1979.
mouse LD50 intravenous > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1589, 1979.
mouse LD50 oral > 5gm/kg (5000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1589, 1979.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1589, 1979.
mouse LD50 unreported > 5gm/kg (5000mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 19, Pg. 606, 1984.
rat LD50 intraperitoneal > 10gm/kg (10000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1589, 1979.
rat LD50 intravenous > 5gm/kg (5000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1589, 1979.
rat LD50 oral > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: NAUSEA OR VOMITING
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1589, 1979.
rat LD50 subcutaneous > 10gm/kg (10000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1589, 1979.
rat LD50 unreported > 5gm/kg (5000mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 19, Pg. 606, 1984.