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Substance Name: Heroin
RN: 561-27-3
UNII: 70D95007SX
InChIKey: GVGLGOZIDCSQPN-PVHGPHFFSA-N

Note

  • A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed)

Molecular Formula

  • C21-H25-N-O5

Molecular Weight

  • 369.4147
 

Classification Codes

Classification Codes

  • Analgesics
  • Analgesics, Opioid
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Human Data
  • Mutation Data
  • Narcotics
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents

Superlist Classification Code

  • DEA Schedule I
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Names and Synonyms

Results Name

  • Heroin

Name of Substance

  • Diacetylmorphine
  • Heroin

MeSH Heading

  • Heroin

Synonyms

  • 3,6-Diacetylmorphine
  • 3,6-O-Diacetylmorphine
  • 7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol diacetate (ester)
  • 7,8-Dihydro-4,5-alpha-epoxy-17-methylmorphinan-3,6-alpha-diol diacetate
  • Acetomorfine
  • Acetomorphine
  • Amsterdam Marble
  • Aspron
  • Black tar [Street Name]
  • Boy [Street Name]
  • China White [Street Name]
  • Crap [Street Name]
  • Diacephin
  • Diacetyl morphine
  • Diacetylmorfin
  • Diacetylmorphine
  • Diamorfina
  • Diamorphine
  • Diaphorm
  • Diasetielmorfien
  • Diasetilmorfin
  • Diasetylmorfiimi
  • Diazetylmorphine
  • Dooje
  • Dujie
  • Eclorion
  • EINECS 209-217-7
  • Eroina
  • H
  • Hairy [Street Name]
  • Harry [Street Name]
  • Heroien
  • Heroiin
  • Heroin
  • Herolan
  • Horse [Street Name]
  • HSDB 6473
  • Indian Pink [Street Name]
  • Iroini
  • Joy powder [Street Name]
  • Junk
  • Malaysian Pink [Street Name]
  • Mexican Brown [Street Name]
  • Morphacetin
  • Morphine diacetate
  • Noise [Street Name]
  • Penang Pink [Street Name]
  • Persian
  • Persian brown [Street Name]
  • Preza
  • Rufus [Street Name]
  • Scag
  • Scag [Street Name]
  • SCOT
  • Smack [Street Name]
  • Stuff
  • TNT (narcotic)
  • UNII-70D95007SX
  • White junk [Street Name]
  • White stuff [Street Name]

Systematic Names

  • Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-, diacetate (ester)
  • Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-, (5alpha,6alpha)-, diacetate (ester)
  • O,O'-Diacetylmorphine

Superlist Names

  • DEA No. 9200
  • Heroin

Registry Numbers

CAS Registry Number

  • 561-27-3

FDA UNII

  • 70D95007SX

Other Registry Number

  • 2078-90-2

Related Registry Number

  • 1502-95-0 (hydrochloride)

System Generated Number

  • 0000561273

Structure Descriptors

InChI

InChI=1S/C21H23NO5/c1-11(23)25-16-6-4-13-10-15-14-5-7-17(26-12(2)24)20-21(14,8-9-22(15)3)18(13)19(16)27-20/h4-7,14-15,17,20H,8-10H2,1-3H3/t14-,15+,17-,20-,21-/m0/s1

InChIKey

GVGLGOZIDCSQPN-PVHGPHFFSA-N

Smiles

CN1CC[C@]23[C@H]4Oc5c(OC(=O)C)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4OC(=O)C)c35

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 20mg/kg (20mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
dog LDLo subcutaneous 25mg/kg (25mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
guinea pig LDLo subcutaneous 400mg/kg (400mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
man TDLo unreported 7821ug/kg/3Y- (7.821mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BLOOD: NORMOCYTIC ANEMIA		 Italian Journal of Neurological Sciences. Vol. 10, Pg. 105, 1989.
mouse LD50 intracrebral 137ug/kg (0.137mg/kg)   European Journal of Pharmacology. Vol. 85, Pg. 317, 1982.
mouse LD50 intravenous 21798ug/kg (21.798mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 468, 1989.
mouse LDLo subcutaneous 262mg/kg (262mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Journal of Pharmacology and Experimental Therapeutics. Vol. 53, Pg. 430, 1935.
rat LD50 intravenous 22500ug/kg (22.5mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 7, Pg. 196, 1952.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 173 deg C   EXP
pKa Dissociation Constant 7.95 (none) 25 EXP
log P (octanol-water) 1.58 (none)   EXP
Water Solubility 600 mg/L 25 EXP
Vapor Pressure 7.59E-10 mm Hg 25 EXP
Henry's Law Constant 6.15E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.30E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.