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Substance Name: Chlorphenoxamine hydrochloride [USP]
RN: 562-09-4
UNII: 5I159322PY
InChIKey: PAQUKACYLLABHB-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H22-Cl-N-O.Cl-H

Molecular Weight

  • 340.292
 
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Names and Synonyms

Name of Substance

  • Chlorphenoxamine hydrochloride [USP]

Synonyms

  • (1-(p-Chlorophenyl)-1-phenyl)ethyl (beta-dimethylaminoethyl) ether hydrochloride
  • 2-((p-Chloro-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethylamine hydrochloride
  • 2-((p-Chloro-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethylethylamine hydrochloride
  • 2-(alpha-(p-Chlorophenyl)-alpha-methylbenzyloxy)-N,N-dimethylethylamine
  • beta-Dimethylaminoethyl (p-chloro-alpha-methylbenzhydryl) ether hydrochloride
  • Chlorphenoxamine HCl
  • Chlorphenoxamine hydrochloride
  • Contristamine, hydrochloride
  • EINECS 209-227-1
  • Ethenamine, 2-(1-(4-chlorophenyl)-1-phenylethoxy)-N,N-dimethyl-, hydrochloride
  • Phenoxene
  • Phenoxene hydrochloride
  • Substanz NR. 1766
  • Substanz NR. 1766 [German]
  • Systral
  • UNII-5I159322PY

Systematic Names

  • Chlorphenoxamine hydrochloride
  • Ethanamine, 2-(1-(4-chlorophenyl)-1-phenylethoxy)-N,N-dimethyl-, hydrochloride (9CI)
  • Ethenamine, 2-(1-(4-chlorophenyl)-1-phenylethoxy)-N,N-dimethyl-, hydrochloride
  • Ethylamine, 2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 562-09-4

FDA UNII

  • 5I159322PY

Related Registry Number

  • 77-38-3 (Parent)

System Generated Number

  • 0000562094

Molecular Formulas

Molecular Formula

  • C18-H22-Cl-N-O.Cl-H

Molecular Formula Fragments

  • C18-H22-Cl-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H22ClNO.ClH/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16;/h4-12H,13-14H2,1-3H3;1H

InChIKey

PAQUKACYLLABHB-UHFFFAOYSA-N

Smiles

c1([C@@](c2ccccc2)(OCCN(C)C)C)ccc(Cl)cc1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 30800ug/kg (30.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Toxicology and Applied Pharmacology. Vol. 4, Pg. 638, 1962.
guinea pig LD50 subcutaneous 220mg/kg (220mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 189, 1954.
mouse LD50 intraperitoneal 161mg/kg (161mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 83, 1960.
mouse LD50 intravenous 44mg/kg (44mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 262, 1954.
mouse LD50 oral 345mg/kg (345mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 262, 1954.
mouse LD50 subcutaneous 159mg/kg (159mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 262, 1954.
rat LD50 oral 1gm/kg (1000mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 31, 1969.