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Substance Name: Torsemide [USAN:USP]
RN: 56211-40-6
UNII: W31X2H97FB
InChIKey: NGBFQHCMQULJNZ-UHFFFAOYSA-N

Note

  • An injectible or oral medication for the treatment of edema associated with congestive heart failure, renal disease and hepatic disease; Na+ 2Cl- K+ symporter inhibitor.

Molecular Formula

  • C16-H20-N4-O3-S

Molecular Weight

  • 348.425
 

Classification Codes

  • Antihypertensive Agents
  • Cardiovascular Agents
  • Diuretic
  • Diuretics
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Natriuretic Agents
  • Reproductive Effect
  • Sodium Potassium Chloride Symporter Inhibitors

Names and Synonyms

Name of Substance

  • Torasemide [INN]
  • Torsemide
  • Torsemide [USAN:USP]

Synonyms

  • 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea
  • 3-Pyridinesulfonamide, N-(((1-methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-
  • AC 4464
  • AC4464
  • BM 02015
  • BM02.015
  • BRN 0498515
  • CCRIS 6736
  • Demadex
  • JDL 464
  • N-(((1-Methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamide
  • Torasemida
  • Torasemida [INN-Spanish]
  • Torasemide
  • Torasemidum
  • Torasemidum [INN-Latin]
  • Torsemide
  • UNII-W31X2H97FB

Systematic Names

  • 3-Pyridinesulfonamide, N-(((1-methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-
  • Torasemide

Registry Numbers

CAS Registry Number

  • 56211-40-6

FDA UNII

  • W31X2H97FB

System Generated Number

  • 0056211406

Structure Descriptors

InChI

1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)

InChIKey

NGBFQHCMQULJNZ-UHFFFAOYSA-N

Smiles

Cc1cccc(c1)Nc2ccncc2S(=O)(=O)NC(=O)NC(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 2gm/kg (2000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22(Suppl,
mouse LD50 unreported > 3gm/kg (3000mg/kg)   Annales Pharmaceutiques Francaises. Vol. 36, Pg. 369, 1978.
rat LD50 intravenous > 500mg/kg (500mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22(Suppl,
rat LD50 oral > 5gm/kg (5000mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22(Suppl,
rat LD50 unreported > 5gm/kg (5000mg/kg)   Annales Pharmaceutiques Francaises. Vol. 36, Pg. 369, 1978.