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Substance Name: Laidlomycin [INN:BAN]
RN: 56283-74-0
UNII: MI3S6ZF5QE
InChIKey: ZNBNBTIDJSKEAM-NISBWGIBSA-N

Note

  • Polycyclic, polyether, monocarboxylic acid posessing inhibitory activity against various Mycoplasma species, especially Acholeplasma laidlawii.

Molecular Formula

  • C37-H62-O12

Molecular Weight

  • 698.8848
 

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product
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Names and Synonyms

Results Name

  • Laidlomycin [INN:BAN]

Name of Substance

  • Laidlomycin
  • Laidlomycin [INN:BAN]

Synonyms

  • 16-Deethyl-3-O-demethyl-16-methyl-3-O-(1-oxopropyl)monensin
  • BRN 1675244
  • EINECS 260-095-1
  • Laidlomicina
  • Laidlomicina [INN-Spanish]
  • Laidlomycin
  • Laidlomycine
  • Laidlomycine [INN-French]
  • Laidlomycinum
  • Laidlomycinum [INN-Latin]
  • UNII-MI3S6ZF5QE

Systematic Name

  • Monensin, 16-deethyl-3-O-demethyl-16-methyl-3-O-(1-oxopropyl)-

Registry Numbers

CAS Registry Number

  • 56283-74-0

FDA UNII

  • MI3S6ZF5QE

System Generated Number

  • 0056283740

Structure Descriptors

InChI

1S/C37H62O12/c1-10-28(40)45-30(24(7)33(41)42)23(6)31-22(5)25(39)17-36(47-31)14-13-34(8,49-36)27-11-12-35(9,46-27)32-20(3)16-26(44-32)29-19(2)15-21(4)37(43,18-38)48-29/h19-27,29-32,38-39,43H,10-18H2,1-9H3,(H,41,42)/t19-,20-,21+,22+,23-,24-,25-,26+,27+,29-,30+,31-,32+,34-,35-,36+,37-/m0/s1

InChIKey

ZNBNBTIDJSKEAM-NISBWGIBSA-N

Smiles

CCC(=O)O[C@H]([C@H](C)[C@H]1O[C@@]2(CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H]4O[C@H](C[C@@H]4C)[C@H]5O[C@@](O)(CO)[C@H](C)C[C@@H]5C)C[C@H](O)[C@H]1C)[C@H](C)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 5mg/kg (5mg/kg)   Journal of Antibiotics. Vol. 27, Pg. 884, 1974.
mouse LD50 intravenous 1mg/kg (1mg/kg)   Journal of Antibiotics. Vol. 27, Pg. 884, 1974.
mouse LD50 subcutaneous 2500ug/kg (2.5mg/kg)   Journal of Antibiotics. Vol. 27, Pg. 884, 1974.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 152 deg C   EXP
log P (octanol-water) 5.740 (none)   EST
Atmospheric OH Rate Constant 1.78E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.