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Substance Name: Afloqualone [INN:JAN]
RN: 56287-74-2
UNII: CO4U2C8ORZ
InChIKey: VDOSWXIDETXFET-UHFFFAOYSA-N

Classification Codes

  • Central Nervous System Agents
  • Dermatologic Agents
  • Drug / Therapeutic Agent
  • Muscle Relaxants, Central
  • Neuromuscular Agents
  • Peripheral Nervous System Agents
  • Photosensitizing Agents
  • Radiation-Sensitizing Agents

Molecular Formula

  • C16-H14-F-N3-O

Molecular Weight

  • 283.305
 
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Names and Synonyms

Name of Substance

  • Afloqualone
  • Afloqualone [INN:JAN]

Synonyms

  • 5-25-15-00102 (Beilstein Handbook Reference)
  • 6-Amino-2-(fluoromethyl)-3-o-tolyl-4(3H)-chinazolinon
  • 6-Amino-2-fluoromethyl-3-(o-tolyl)-4(3H)-quinazolinone
  • 6-Amino-3,4-dihydro-2-fluoromethyl-3-(2-methylphenyl)-4-chinazolinon
  • Afloqualon
  • Afloqualona
  • Afloqualona [INN-Spanish]
  • Afloqualone
  • Afloqualonum
  • Afloqualonum [INN-Latin]
  • Aroft
  • Arofuto
  • BRN 0819769
  • HQ 495
  • UNII-CO4U2C8ORZ

Systematic Names

  • 4(3H)-Quinazolinone, 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)- (9CI)
  • 4(3H)-Quinazolinone, 6-amino-2-fluoromethyl-3-(o-tolyl)-
  • 6-Amino-2-(fluoromethyl)-3-o-tolyl-4(3H)-quinazolinone

Registry Numbers

CAS Registry Number

  • 56287-74-2

FDA UNII

  • CO4U2C8ORZ

System Generated Number

  • 0056287742

Structure Descriptors

InChI

1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3

InChIKey

VDOSWXIDETXFET-UHFFFAOYSA-N

Smiles

n1(c2c(cccc2)C)c(nc2ccc(cc2c1=O)N)CF

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 272mg/kg (272mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 991, 1983.
mouse LD50 oral 397mg/kg (397mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 991, 1983.
mouse LD50 subcutaneous 591mg/kg (591mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 991, 1983.
rat LD50 intraperitoneal 385mg/kg (385mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 991, 1983.
rat LD50 oral 249mg/kg (249mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 991, 1983.
rat LD50 subcutaneous 823mg/kg (823mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 991, 1983.