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Substance Name: PR-Toxin
RN: 56299-00-4
UNII: F9W0X88AFM
InChIKey: GSPFUBNBRPVALJ-VIEAGMIOSA-N

Note

  • Mycotoxin from Penicillium roqueforti.

Molecular Formula

  • C17-H20-O6

Molecular Weight

  • 320.339
 

Classification Codes

  • Mutation Data
  • Natural Product
  • Tumor Data
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Names and Synonyms

Name of Substance

  • PR toxin
  • PR-Toxin

Synonyms

  • CCRIS 4938
  • HSDB 7247
  • PR toxin
  • PR toxine
  • PR toxine [French]
  • PR-Toxin
  • PRT
  • Toxin (Penicillium roquefortii)
  • Toxin PR
  • UNII-F9W0X88AFM

Systematic Names

  • PR toxin
  • Spiro(naphth(1,2-b)oxirene-5(1aH),2'-oxirane)-3'-carboxaldehyde, 2-(acetyloxy-2,3,3a,4,6,7b-hexahydro-3,3',3a-trimethyl-6-oxo-, (1aR,2R,2'R,3R,3'S,3aR,7bS)-
  • Spiro(naphthalene-2(1H),2'-oxirane)-3'-carboxaldehyde, 3,5,6,7,8,8a-hexahydro-7-acetoxy-5,6-epoxy-3',8,8a-trimethyl-3-oxo-

Registry Numbers

CAS Registry Number

  • 56299-00-4

FDA UNII

  • F9W0X88AFM

System Generated Number

  • 0056299004

Structure Descriptors

InChI

1S/C17H20O6/c1-8-12(21-9(2)19)14-13(22-14)10-5-11(20)17(6-15(8,10)3)16(4,7-18)23-17/h5,7-8,12-14H,6H2,1-4H3/t8-,12+,13-,14+,15+,16+,17-/m0/s1

InChIKey

GSPFUBNBRPVALJ-VIEAGMIOSA-N

Smiles

C[C@H]1[C@@H](OC(=O)C)[C@H]2O[C@H]2C3=CC(=O)[C@]4(C[C@]13C)O[C@]4(C)C=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2mg/kg (2mg/kg) BEHAVIORAL: FLUID INTAKE

BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Food and Cosmetics Toxicology. Vol. 16, Pg. 369, 1978.
mouse LD50 intravenous 2mg/kg (2mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 6, Pg. 116, 1981.
mouse LD50 oral 72mg/kg (72mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: FLUID INTAKE
Food and Cosmetics Toxicology. Vol. 16, Pg. 369, 1978.
rat LD50 intraperitoneal 11600ug/kg (11.6mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: MUSCLE WEAKNESS
Toxicon. Vol. 20, Pg. 433, 1982.
rat LD50 intravenous 8200ug/kg (8.2mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: MUSCLE WEAKNESS
Toxicon. Vol. 20, Pg. 433, 1982.
rat LDLo oral 115mg/kg (115mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

GASTROINTESTINAL: OTHER CHANGES
Applied Microbiology. Vol. 25, Pg. 111, 1973.