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Substance Name: Tocamphyl [USAN:INN]
RN: 5634-42-4
UNII: 9C8C4SBN10
InChIKey: WSEQDEFUEFCRLT-MULMSPGLSA-N

Classification Codes

  • Choleretic
  • Drug / Therapeutic Agent

Molecular Formula

  • C19-H26-O4.C4-H11-N-O2

Molecular Weight

  • 423.5463
 
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Names and Synonyms

Name of Substance

  • Tocamphyl
  • Tocamphyl [USAN:INN]

Synonyms

  • 1,3-Cyclopentanedicarboxylic acid, 1,2,2-trimethyl-, 1-(1-(4-methylphenyl)ethyl) ester, compd. with 2,2'-iminobis(ethanol) (1:1)
  • 1,3-Cyclopentanedicarboxylic acid, 1,2,2-trimethyl-, 1-(1-(4-methylphenyl)ethyl)ester, compd. with 2,2'-iminobis(ethanol)(1:1)
  • 1-(p,alpha-Dimethylbenzyl) camphorate compound with 2,2'-iminodiethanol (1:1)
  • Benzyl alcohol, p,alpha-dimethyl-, 3-hydrogen (+)-camphorate, compd. with 2,2'-iminodiethanol (1:1)
  • Biliphorin
  • Biliphorine
  • Diethanolamine p-tolylmethylcarbinol camphorate
  • Diethanolamine salt of the mono-(+)-camphoric acid ester of p-tolylmethylcarbinol
  • EINECS 227-081-7
  • Gallogen
  • Gallogen (choleretic)
  • Hepasynthyl
  • Hepatoxane
  • Licarbin
  • Lymethol
  • Syncuma
  • Synthobilin
  • Tocamphyl
  • Tocamphylum
  • Tocamphylum [INN-Latin]
  • Tocanfil
  • Tocanfil [INN-Spanish]
  • Tolylmethyl carbinol mono-D-camphoric acid ester, diethanolamine salt
  • UNII-9C8C4SBN10

Systematic Names

  • 1,3-Cyclopentanedicarboxylic acid, 1,2,2-trimethyl-, 1-(1-(4-methylphenyl)ethyl) ester, compd. with 2,2'-iminobis(ethanol) (1:1)
  • Camphoric acid, 1-(p,alpha-dimethylbenzyl) ester, compd. with 2,2'-iminodiethanol (1:1)
  • Camphoric acid, p,alpha-dimethylbenzyl ester, compd. with 2,2'-iminodiethanol
  • Ethanol, 2,2'-iminobis-, 1-(1-(4-methylphenyl)ethyl) 1,2,2-trimethyl-1,3-cyclopentanedicarboxylate (salt)
  • Ethanol, 2,2'-iminodi-, 1-(p,alpha-dimethylbenzyl)camphorate (salt)
  • Synthobilin
  • Tocamphyl

Registry Numbers

CAS Registry Number

  • 5634-42-4

FDA UNII

  • 9C8C4SBN10

System Generated Number

  • 0005634424

Molecular Formulas

Molecular Formula

  • C19-H26-O4.C4-H11-N-O2

Molecular Formula Fragments

  • C19-H26-O4
  • C4-H11-N-O2
  • COMPONENT

Structure Descriptors

InChI

1S/C19H26O4.C4H11NO2/c1-12-6-8-14(9-7-12)13(2)23-17(22)19(5)11-10-15(16(20)21)18(19,3)4;6-3-1-5-2-4-7/h6-9,13,15H,10-11H2,1-5H3,(H,20,21);5-7H,1-4H2/t13?,15-,19+;/m1./s1

InChIKey

WSEQDEFUEFCRLT-MULMSPGLSA-N

Smiles

CC(OC(=O)[C@]1(C)CC[C@H](C(=O)O)C1(C)C)c2ccc(C)cc2.OCCNCCO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. 6, Pg. 504, 1982.
mouse LD50 subcutaneous 500mg/kg (500mg/kg)   Drugs in Japan Vol. 6, Pg. 504, 1982.
rat LD50 intramuscular 1200mg/kg (1200mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 222, Pg. 244, 1954.
rat LD50 oral 2808mg/kg (2808mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 5121, 1993.
rat LD50 subcutaneous 500mg/kg (500mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.